Zabia 50 mg Tablets (Sitagliptin Hydrochloride Hydrate)

Adult dose

The usual dose is 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. In patients with moderate renal impairment (glomerular filtration rate [eGFR] ≥ 30 mL/min/1.73 m2 and < 45 mL/min/1.73 m2), 50 mg is administered once daily. In patients with severe renal impairment (glomerular filtration rate [eGFR] ≥ 15 mL/min

This medication may cause severe allergic reactions after administration, so if you experience symptoms such as skin rash or difficulty breathing, you should stop taking the medication immediately and consult a physician. Additionally, this medication can cause serious pancreatic inflammation known as pancreatitis, so if symptoms such as abdominal pain, vomiting, or loss of appetite occur, you should inform healthcare professionals immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and should not be administered if there is a severe allergic reaction to this medication or the ingredients. Patients with reduced kidney function may have delayed elimination of this medication, so dosage adjustment may be necessary, and it is important to undergo periodic kidney function tests. Hypoglycemic symptoms may occur while on this medication, so when used with insulin or sulfonylurea, dosage adjustments might be needed to reduce the risk of hypoglycemia. Furthermore, if symptoms such as joint pain or skin blistering occur, you should inform your physician immediately and cease taking the medication. It is recommended that pregnant or breastfeeding women do not use this medication and that it is avoided in children under 18 years, as safety and efficacy have not been established. Elderly patients may have reduced kidney function, so it is important to assess kidney function before and after administration and use with caution. In case of overdose, appropriate treatment should be sought immediately at a medical facility, as this medication can be partially removed by hemodialysis, and dialysis treatment may be considered if necessary.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, Stevens-Johnson syndrome, severe skin adverse reactions, acute pancreatitis, severe hypoglycemia, acute renal failure, joint pain with severe and disabling conditions, bullous pemphigoid

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• diarrhea
• nausea
• constipation
• muscle pain
• limb pain
• back pain
• pruritus

This medication should be stored in a tightly sealed container to prevent air and moisture from entering, and it is safest to keep it at room temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness and prevents deterioration.

Appearance

Bright orange, biconvex, round film-coated tablet

Package unit

30 tablets/box [10T/PTP*3]