Januvex Tablets 50/850 mg (Sitagliptin Hydrochloride Monohydrate, Metformin Hydrochloride)

Adult dose

This medication is generally taken 2 times a day with food, and the dose is gradually increased to reduce gastrointestinal adverse reactions associated with metformin. 1. Patients not currently treated with metformin: Take one tablet of this medication 50/500 mg twice daily; may increase to 50/1000 mg. 2. Patients currently treated with metformin: Recommended initial dosage is sitagliptin...

This medication consists of two components, each with different precautions. First, the sitagliptin component may rarely cause serious allergic reactions. Symptoms of such reactions may include difficulty breathing, swelling of the face or neck, and severe skin rashes. If such symptoms occur, immediately stop taking this medication and consult a doctor. Additionally, sitagliptin may cause inflammation of the pancreas, so if abdominal pain, vomiting, or nausea occurs, seek medical attention promptly. Second, the metformin component can cause a rare but potentially life-threatening condition known as lactic acidosis. This condition may present with symptoms such as muscle pain, difficulty breathing, lethargy, and abdominal pain; if such symptoms occur, immediately discontinue the medication and contact a medical facility. This medication should not be administered to patients with severely impaired kidney function or those with serious infections, dehydration, or acute heart disease. Moreover, pregnant or nursing women should avoid its use. During treatment, regular kidney function tests should be conducted, and elderly patients should be especially cautious as they are at higher risk for impaired kidney function. Furthermore, taking this drug in conjunction with other diabetes medications or alcohol may increase the risk of hypoglycemia, thus blood sugar levels should be frequently monitored and dosage adjustments should be made as needed in consultation with a doctor. Before undergoing surgery or imaging tests involving contrast agents, this medication should be temporarily discontinued, and it should only be resumed after confirming normal kidney function following the tests. Side effects such as diarrhea, nausea, vomiting, headache, upper respiratory infection, may occur during treatment. If any symptoms are severe or persistent, consult a physician. Lastly, if any unusual symptoms such as rapid weight loss, loss of appetite, skin rashes, joint pain, or blistering skin disorders occur during treatment, promptly inform healthcare personnel.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, rash, exfoliative skin diseases (Stevens-Johnson syndrome), severe allergic reactions, acute pancreatitis, hemorrhagic or necrotizing pancreatitis, acute renal failure, difficulty breathing, severe and disabling joint pain, blistering dermatitis, acute renal failure, difficulty breathing, unstable angina, severe lactic acidosis, severe symptoms due to hypoglycemia, jaundice, elevated liver enzymes, severe edema

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• muscle pain
• limb pain
• back pain

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is advisable to keep the storage temperature between 1 and 30 degrees Celsius at room temperature. Proper storage will help maintain the medication's effectiveness for a prolonged period.

Appearance

Pink oval film-coated tablet

Package unit

60 tablets/box [10 tablets/PTP x 6]