Januvex 50/500 mg (Sitagliptin Hydrochloride Monohydrate, Metformin Hydrochloride)

Adult dose

This medication is taken twice a day with food, and the dosage is gradually increased to reduce gastrointestinal adverse effects of metformin. 1. For patients not previously treated with metformin: - Initial dose: 1 tablet (50/500 mg) twice a day - Possible increase: 1 tablet (50/1000 mg) twice a day 2. For patients currently on metformin treatment: - Initial dose: Total daily sitagliptin of 100 mg

This medication contains sitagliptin and metformin, which are used in the treatment of diabetes. Firstly, severe allergic reactions may occur during the use of this medication, so if symptoms such as skin rash, hives, or difficulty breathing occur, discontinue use immediately and consult a doctor. Additionally, acute pancreatitis, an inflammation of the pancreas, may occur, so if symptoms such as abdominal pain, nausea, or vomiting arise, inform healthcare professionals immediately. This medication should not be administered to patients with poor kidney function or those with acute heart failure, myocardial infarction, or severe infections, especially as the risk of lactic acidosis, a serious side effect, increases in patients with impaired kidney function. Lactic acidosis is a rare complication that occurs when excess lactic acid accumulates in the body, which may present symptoms such as muscle pain, weakness, difficulty breathing, abdominal pain, or decreased consciousness; such symptoms require immediate hospital attention. During the use of this medication, regular kidney function and blood tests should be conducted to check for abnormalities, especially in the elderly or those with low kidney function. Furthermore, this medication may cause hypoglycemia, so caution should be exercised when skipping meals or engaging in vigorous exercise, and when combined with other hypoglycemic agents, the risk of hypoglycemia may increase. Patients scheduled for surgery should discontinue this medication 48 hours prior to the surgery and can resume after kidney function has normalized post-surgery. It is safer for pregnant women or those who may become pregnant, as well as breastfeeding mothers, to avoid this medication. Additionally, excessive alcohol consumption should be avoided while taking this medication as it may increase the risk of lactic acidosis. Other medications may interact with this medication, so be sure to inform healthcare professionals of any currently taken medications. Finally, it is important to consult with healthcare professionals immediately if you experience any abnormal symptoms or discomfort during the use of this medication to receive appropriate measures.

Serious side effects

• Hives
• angioedema
• anaphylaxis
• Stevens-Johnson syndrome
• rash
• cutaneous vasculitis
• exfoliative skin diseases
• hemorrhagic or necrotizing pancreatitis
• acute pancreatitis
• acute renal failure

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infection
• rhinitis
• headache
• hypoglycemia
• myalgia
• limb pain

This medication should be stored in a sealed container to prevent air exposure, ideally at room temperature between 1 and 30 degrees Celsius. This will help maintain its effectiveness and prevent deterioration.

Appearance

Bright pink oval film-coated tablet

Package unit

60 tablets/box [10 tablets/PTP x 6]