Januse Tablet 50 mg (Sitagliptin Hydrochloride Hydrate)

Adult dosage

The recommended dose of this medication is 100 mg once daily, either as monotherapy or in combination therapy, with a maximum daily dosage of 100 mg. It can be taken regardless of meals. In patients with renal impairment, dosage adjustments are required based on glomerular filtration rate. - In mild renal impairment (eGFR 60 or above but less than 90), no dosage adjustment is needed. - In moderate renal impairment (eGFR 45 or above but less than 60), no dosage adjustment is needed. -

This medication may cause serious allergic reactions; therefore, if symptoms such as skin rash or swelling occur, discontinue use immediately and consult a physician. Additionally, acute pancreatitis, a serious inflammation of the pancreas, may occur, so if symptoms such as abdominal pain or vomiting develop, notify healthcare personnel immediately. Patients with type 1 diabetes or diabetic ketoacidosis should not use this medication, nor should it be administered to those with a severe allergy to this drug or its ingredients. Patients with impaired kidney function may need dosage adjustments, and regular kidney function tests are recommended. During treatment with this medication, hypoglycemic symptoms may occur, particularly when used with insulin or sulfonylureas, so blood sugar levels should be closely monitored. If severe joint pain or skin blistering symptoms occur, inform a doctor immediately, and this medication may need to be discontinued if necessary. Women who are pregnant or breastfeeding are advised not to use this medication, and its safety and efficacy have not been established in children under 18 years of age. In case of overdose, seek immediate medical attention, as this medication can be partially removed by hemodialysis, so dialysis treatment may be considered if necessary. During treatment, there may be drug interactions, so it is important to inform healthcare personnel of all medications being taken and to receive regular monitoring.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, severe skin reactions (Stevens-Johnson syndrome, exfoliative skin disease), acute pancreatitis, severe edema, acute kidney failure, severe and disabling arthralgia, bullous pemphigoid, jaundice (liver dysfunction), severe allergic reactions, severe hypoglycemia, pneumonia, cardiac arrest

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• constipation
• vomiting
• myalgia
• limb pain
• back pain
• pruritus
• thrombocytopenia

Store this medication in a sealed container that prevents air from entering, and keep it at room temperature between 1°C and 30°C. This storage method helps maintain the effectiveness of the drug and prevents deterioration.

Appearance

Bright orange, convex-shaped film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP x 3]