Glyfloem Controlled-Release Tablets 10/500 mg

Adult dose

This medication is generally taken once a day with the evening meal. The maximum dosage is dapagliflozin 10 mg/metformin controlled-release 2000 mg taken once daily, or 2 tablets of 5 mg/1000 mg. The recommended starting dosage for initial therapy is 1 tablet of 5 mg/500 mg or 10 mg/500 mg once daily. To reduce gastrointestinal side effects of metformin, dosage should be adjusted gradually.

This medication is used in the treatment of diabetes and should not be used in patients with impaired kidney function or specific health conditions. It can rarely cause a serious condition called lactic acidosis, so caution is required in patients with decreased kidney function or those with heart disease or infections. When used with insulin or sulfonylureas, the risk of hypoglycemia may increase, so dosage adjustment may be necessary. Additionally, it should be administered carefully in patients at risk of dehydration or hypotension, with close monitoring of fluid status and kidney function before and during administration. The risk of genital infections and urinary tract infections may increase, so immediate treatment should be sought if symptoms of infection appear. Pregnant or breastfeeding women should not take this medication, and if pregnancy is confirmed, treatment should be discontinued. Elderly patients or those with impaired kidney function may need dosage adjustments, and regular kidney function tests are required. Excessive alcohol consumption should be avoided during treatment, and the medication should be temporarily suspended prior to any sudden surgeries or imaging tests involving contrast agents. In case of overdose, immediate medical attention should be sought for appropriate treatment, and the safety and efficacy of this medication in children have not been established. Lastly, this medication should be kept out of reach of children and stored in its original container to prevent degradation of quality.

Serious side effects

Severe lactic acidosis, severe hypoglycemia, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), severe skin reactions (severe rash with fever, blistering, skin peeling, pain in oral/ocular mucosa), respiratory problems (shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever), liver abnormalities (jaundice, yellowing of skin or eyes, systemic symptoms).

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia (when used with sulfonylureas or insulin), reduced fluid volume (including dehydration, hypovolemia, hypotension), thirst, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, increased hematocrit, initial decrease in renal creatinine clearance, dyslipidemia, initial increase in blood levels.

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain storage temperatures between 1 and 30 degrees Celsius. This will help preserve the medication's efficacy and safety.

Appearance

Pink, oval, double convex, controlled-release film-coated tablets

Package unit

30 tablets/box[(6 tablets/PTP)*5], 30 tablets/bottle