Daploem Sustained Release Tablets 10/500 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dosage is once daily dapagliflozin 10 mg/sustained release metformin 2000 mg, given as two tablets of 5 mg/1000 mg. When used as initial therapy, the recommended starting dosage is one tablet once daily of either 5 mg/500 mg or 10 mg/500 mg. Dosing should be adjusted gradually to minimize gastrointestinal side effects from metformin.

This medication may cause rare side effects such as severe lactic acidosis, so it should not be administered to patients with impaired kidney function, severe infections, or dehydration. Additionally, caution should be exercised for the risk of hypoglycemia when used in conjunction with insulin or sulfonylurea medications. Patients with moderate to severe renal impairment, those with acute myocardial infarction or heart failure, and those scheduled for surgery should consult their physician before administration. This medication is not to be used in pregnant or breastfeeding women, or patients with specific genetic issues like lactose intolerance. Symptoms of fluid volume decrease or hypotension may occur during treatment, so blood pressure and renal function should be monitored regularly. There is an increased risk of genital infections or urinary tract infections, so medical attention should be sought immediately upon the appearance of related symptoms. Vitamin B12 levels may decrease; thus, blood vitamin B12 levels should be checked with long-term use. Alcohol consumption can increase the risk of lactic acidosis, so excessive drinking should be avoided. This medication does not significantly affect driving or machinery operation, but dizziness may occur, so caution is advised. Keep out of reach of children and store in the original container.

Serious side effects

• Lactic acidosis
• severe hypoglycemia
• ketoacidosis
• urosepsis
• pyelonephritis
• acute kidney injury
• renal impairment
• perineal necrosis
• severe allergic reactions
• severe skin reactions

Mild side effects

Vulvovaginitis, balanitis, and related genital infections, urinary tract infections, hypoglycemia (when used with insulin or sulfonylureas), reduced fluid volume (dehydration, hypovolemia, hypotension), thirst, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, increased hematocrit, reduced initial renal creatinine clearance, dyslipidemia, elevated serum creatinine, elevated blood urea,

This medication should be stored in a tightly sealed container to prevent contact with air or moisture. The storage temperature should ideally be maintained at room temperature between 1°C and 30°C. Proper storage will help maintain the medication’s efficacy and safety.

Appearance

Pink, biconvex, oval-shaped sustained release film-coated tablet

Package unit

30 tablets/box [(6 tablets/PTP) * 5], 30 tablets/bottle