Sitagliptin Tablet 25mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

This medication is administered once daily at a dose of 100mg for monotherapy or combination therapy, with a maximum daily dose of 100mg. It may be taken regardless of meals. In patients with moderate renal impairment (glomerular filtration rate 30-45ml/min/1.73㎡), a dose of 50mg is administered once daily. Patients with severe renal impairment (glomerular filtration rate 15-30ml/min/1.73㎡) or those requiring hemodialysis or peritoneal dialysis should receive a dose of 25mg once daily.

This medication may cause severe allergic reactions after administration; if symptoms such as skin rash or difficulty breathing occur, discontinue use immediately and consult a physician. During the use of this medication, serious pancreatic inflammation (acute pancreatitis) may occur; thus, any symptoms such as abdominal pain or vomiting should be reported to medical personnel immediately. Patients with type 1 diabetes or diabetic ketoacidosis should not use this medication; it should also be avoided in individuals with allergies to this drug or its components. Patients with impaired kidney function must have their dosage adjusted for this medication, so those with renal disease should consult their healthcare provider. In clinical trials, patients taking this medication primarily reported side effects such as upper respiratory tract infections, headaches, nasopharyngitis, and diarrhea, while the risk of hypoglycemia may increase, particularly when used in combination with insulin or sulfonylureas. This medication can cause symptoms of hypoglycemia when taken with other antidiabetic agents, thus dose adjustments may be necessary when taken with insulin or sulfonylureas. Severe joint pain or blistering skin diseases may occur; if these symptoms appear, inform your physician immediately and stop taking the medication. This medication generally has fewer interactions with certain drugs, but caution is needed when taken with cyclosporine or digoxin, and monitoring by medical personnel is required. Pregnant or breastfeeding women are advised not to take this medication, and its use in patients under 18 years of age should be avoided due to the lack of established safety and efficacy. Elderly patients may have reduced kidney function, thus regular kidney function tests are important before and after taking this medication. In cases of overdose, unabsorbed medication should be removed, and clinical monitoring including cardiac condition should be performed; if necessary, some medications can be removed through hemodialysis.

Serious side effects

Urticaria, severe swelling (angioedema), tightness in the chest, shortness of breath, anaphylaxis, Stevens-Johnson syndrome, severe skin reactions, acute pancreatitis, severe allergic reactions, acute renal failure, joint pain accompanied by severe symptoms and disability, bullous pemphigoid, liver abnormalities (elevated liver enzymes, jaundice), severe neurological symptoms, severe edema accompanied by hypertension, cardiac arrest

Mild side effects

• Hypoglycemia
• upper respiratory infections
• nasopharyngitis
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• myalgia

This medication should be stored in a tightly sealed container to prevent air and moisture exposure, ideally at room temperature between 1°C and 30°C. This helps maintain its effectiveness and ensures safe use.

Appearance

Bright yellow-orange round film-coated tablet

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle