Enblomet Extended-Release Tablet 0.3/1000 mg (Inavogliflozin, Metformin Hydrochloride)

Adult dose

This medication is administered once daily, one tablet with meals to patients receiving inavogliflozin 0.3 mg and extended-release metformin hydrochloride 1000 mg.

This medication contains metformin hydrochloride and inavogliflozin, and is used for the treatment of diabetes. Caution is necessary as serious side effects such as lactic acidosis may occur when taking this medication. Lactic acidosis is a condition that occurs when there is an excessive accumulation of lactic acid in the body, which can be life-threatening in severe cases. Patients with significantly reduced kidney function, serious infection, dehydration, or acute heart failure should not use this medication. Additionally, patients with type 1 diabetes or a history of diabetic ketoacidosis should not use this medication. While taking this medication, fluid volume may decrease or kidney function may be affected, so elderly patients or those taking diuretics should regularly monitor their fluid status and kidney function. Moreover, this medication has blood sugar-lowering effects, thus irregular meals, intense exercise, or excessive alcohol consumption can increase the risk of hypoglycemia, necessitating caution. The inavogliflozin component of this medication may increase the risk of urinary tract infections or genital infections, so should any symptoms of infection arise, prompt consultation with healthcare professionals is advised. Women who are pregnant or planning to become pregnant should avoid using this medication, and breastfeeding mothers should also avoid it. Elderly patients are at higher risk of decreased kidney function, and therefore need to be monitored more closely when using this medication. Gastrointestinal disturbances (nausea, vomiting, diarrhea, etc.) may occur during treatment; these symptoms commonly happen early in treatment but should be reported to healthcare professionals if severe. This medication may interact with other drugs; hence, if other medications are being taken, it is essential to inform healthcare professionals, especially when taking drugs that may affect kidney function. If undergoing surgery or tests using iodine contrast agents, this medication should be temporarily discontinued and resumed only after confirming normal kidney function. This medication should not be crushed or chewed but swallowed whole, and weight changes should be monitored periodically as weight loss may occur. In case of overdose, contact healthcare professionals immediately and receive appropriate treatment based on the symptoms.

Serious side effects

Hives, lactic acidosis, suspected symptoms of lactic acidosis (malaise, muscle pain, shortness of breath, weakness, abdominal pain), symptoms of ketoacidosis (nausea, vomiting, upper abdominal pain, malaise, shortness of breath), severe lactic acidosis, severe allergic reactions (hives), mental confusion, altered consciousness, severe cutaneous adverse reactions (severe rash with fever, blisters, skin peeling, oral/ocular mucosal pain), shortness of breath, difficulty breathing, liver abnormalities (jaundice).

Mild side effects

• Indigestion
• constipation
• gastritis
• upper abdominal pain
• abdominal pain
• diarrhea
• dry mouth
• small bowel-colitis
• bloody stool
• vaginal infection

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. Additionally, it is important to maintain a cool room temperature between 1 degree and 30 degrees Celsius for storage. Doing so will help maintain the effectiveness and ensure safe use of the medication.

Appearance

White and light pink oval-shaped extended-release bilayer tablet

Package unit

30 tablets/bottle, 300 tablets/bottle, 28 tablets/box [(7 tablets/PTP) X 4]