Medication info
Tosjet A Tablet 10/20/5 mg (Ezetimibe, Atorvastatin Calcium Hydrate, Amlodipine Besylate)

Tosjet A Tablet 10/20/5 mg (Ezetimibe, Atorvastatin Calcium Hydrate, Amlodipine Besylate)

Prescription medicationTablet경구
Ingredient · strength
Atorvastatin Calcium Trihydrate›21.7mg / 1 tabletAmlodipine Besylate›6.944mg / 1 tabletEzetimibe›10mg / 1 tablet
Manufacturer / importer
에스케이케미칼(주)
Appearance
Yellow rectangular film-coated tablet
Packaging
30 tablets/box [(10 tablets/PTP x 3)]
Approval status
Active

MFDS item code 202301716 · Approved 2023.05.31

Summary

Main use
Treatment of hypertension and angina (myocardial ischemia), improvement of hypercholesterolemia and dyslipidemia.
Who takes it
Adults
Adult dose
The recommended dosage of this medication is once daily, 1 tablet, taken with water regardless of meals. It is advised to take it at the same time each day (e.g., in the morning) if possible. This medication should be swallowed whole without chewing, splitting, or crushing. Amlodipine: Administer 5 mg orally once daily, and it may be increased to a maximum of 10 mg daily depending on the patient's response. Ezetimibe/Atorvastatin combination: Regardless of meals.

Ingredients

Manufacturer
에스케이케미칼(주)

Efficacy & effects

Treatment of hypertension and angina (myocardial ischemia), improvement of hypercholesterolemia and dyslipidemia.

  • Hypertension
  • fixed occlusion of the coronary arteries
  • coronary vascular spasms
  • vasoconstriction
  • myocardial ischemia
  • primary hypercholesterolemia
  • heterozygous familial hypercholesterolemia
  • non-familial hypercholesterolemia
  • mixed dyslipidemia
  • homozygous familial hypercholesterolemia.
View approved original text

This medication is administered to patients with angina symptoms due to hypertension or coronary artery disease, and particularly helps improve myocardial ischemia caused by vasoconstriction or vascular spasms. Additionally, in patients recently confirmed with coronary artery disease through angiography without heart failure and with normal cardiac output, it effectively reduces the risk of hospitalization due to angina and decreases the risks associated with coronary artery revascularization. Moreover, it assists in lowering bad cholesterol levels and raising good cholesterol levels in patients with primary hypercholesterolemia and mixed dyslipidemia. Especially for patients with homozygous familial hypercholesterolemia, this medication is used either in conjunction with other treatments or as an alternative treatment, and it is expected to reduce morbidity and mortality associated with cardiovascular diseases. This medication is used effectively to manage cardiovascular disease and hyperlipidemia.

How to take

Adult dose

The recommended dosage of this medication is once daily, 1 tablet, taken with water regardless of meals. It is advised to take it at the same time each day (e.g., in the morning) if possible. This medication should be swallowed whole without chewing, splitting, or crushing. Amlodipine: Administer 5 mg orally once daily, and it may be increased to a maximum of 10 mg daily depending on the patient's response. Ezetimibe/Atorvastatin combination: Regardless of meals.

Precautions

This medication may cause serious abnormalities in muscles, so if severe muscle pain or weakness occurs, consult a doctor immediately. In particular, it should be temporarily stopped or discontinued in cases of acute infection, hypotension, major surgery, trauma, or severe metabolic disorders. Individuals allergic to ingredients in this medication or similar drugs, those with severe liver disease, muscle disease, pregnant or potentially pregnant women, and nursing mothers should not take this medication. Alcoholics, individuals with weakened liver function, those with impaired kidney function, elderly individuals over 70 years, and those taking specific medications should use this medication with caution. This medication can affect liver function; therefore, consult a doctor if liver function test results are abnormal, and regular liver function tests should be conducted during treatment. If muscle pain, muscle weakness, fatigue, or fever occurs during the use of this medication, notify a doctor immediately, and if necessary, blood tests should be conducted to check for muscle damage. If taking this medication along with certain antibiotics, antiviral agents, immunosuppressants, or other lipid-lowering agents, the risk of muscle damage may increase, so inform the doctor of all medications being taken. Pregnant women or those planning to be pregnant should not take this medication, and those who are taking it should use appropriate contraception. Caution should be exercised as dizziness may occur when driving or operating machinery. This medication contains lactose, so those with lactose intolerance should be mindful of its use.

Side effects and when to seek care immediately

Serious side effects

  • Hives
  • severe swelling
  • chest tightness
  • difficulty breathing
  • cold sweat
  • pallor
  • rash
  • blisters
  • skin peeling
  • oral/eye mucosal pain
Show 16 more
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • severe allergic reactions
  • severe skin adverse reactions
  • respiratory problems
  • jaundice
  • liver abnormalities
  • sudden and severe headache
  • thunderclap headache
  • seizures
  • confusion
  • vision abnormalities
  • paralysis
  • significantly reduced urine output
  • generalized severe edema
  • blood pressure.

Mild side effects

  • Headache
  • constipation
  • indigestion
  • diarrhea
  • fatigue
  • chest pain
  • edema
  • dry eyes
  • ingrown toenail
  • palpitations
Show 25 more
  • joint pain
  • weakness
  • lethargy
  • weight changes
  • hypotension
  • vasculitis
  • tension
  • sensory loss
  • peripheral neuropathy
  • syncope
  • taste disorder
  • tremors
  • extrapyramidal disorder
  • erectile dysfunction
  • gynecomastia
  • vomiting
  • pancreatitis
  • nausea
  • changes in bowel habits
  • dry mouth
  • cough
  • shortness of breath
  • rhinitis
  • thrombocytopenia
  • insomnia.

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is advisable to maintain the storage temperature between 1°C and 30°C at room temperature. Storing it this way will secure the effectiveness of the medication.

Appearance and packaging

Appearance

Yellow rectangular film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.