Atovamib Tablets 10/5 mg (Ezetimibe, Atorvastatin Calcium Trihydrate)

Adult dosage

This drug is administered once daily, regardless of meals. For primary hypercholesterolemia, the dosage range is 10/5 mg to 10/80 mg once daily. Initial dosage of 10/5 mg, 10/10 mg, or 10/20 mg is recommended. In patients requiring greater reduction of LDL-cholesterol (more than 55%), an initial dose of 10/40 mg is recommended. After administration or dosage adjustment, check blood lipid levels at intervals of more than 2 weeks.

This drug may cause serious muscle problems, so if symptoms such as muscle pain or weakness occur, inform a doctor immediately. In particular, if there are risk factors such as severe infection, trauma, or post-surgery, the use of this drug should be paused temporarily. It should not be taken by those with allergies to the ingredients, liver disease, muscle disorders, or women who are pregnant or breastfeeding. Those with alcoholism, poor liver function, kidney problems, and hypothyroidism should use this drug with caution. This drug may affect liver function, so liver function tests should be conducted before and during treatment. Additionally, during use of this drug, one should closely monitor for symptoms of muscle pain or weakness, fatigue, and fever. This drug can interact with other medications, so inform a doctor or pharmacist of any current medications. Women of childbearing age should use appropriate contraception to avoid pregnancy while taking this drug, and if pregnancy is confirmed, use should be stopped immediately. The safety and efficacy of this drug have not been established in children and is therefore not recommended. Elderly patients are at higher risk of myopathy and should use caution during treatment. In cases of overdose, there are no specific antidotes, and treatment should be symptomatic while monitoring liver function and muscle enzyme levels.

Serious side effects

• Urticaria
• skin rash
• angioedema
• anaphylaxis
• severe rash with fever
• blisters
• skin peeling
• mucosal pain in the mouth/eyes
• shortness of breath
• asthma attack

Mild side effects

• Abdominal pain
• dizziness
• headache
• osteochondritis
• cough
• pruritus
• gastritis
• colon polyps
• sensory loss
• back pain

This drug should be stored in a tightly closed container to protect it from air and moisture, maintaining storage temperature between 1 and 30 degrees Celsius at room temperature. It is important to avoid direct sunlight and not to store it in excessively hot or cold places.

Appearance

Pink oblong film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP x 3]