Mavacamten 15 mg Capsule (Mavacamten)

Adult dose

The recommended starting dose of this drug is 5 mg orally once daily, with or without food. Swallow this drug whole with water. Do not open, crush, or chew the capsule. The patient's initial clinical response should be assessed 4 weeks after starting treatment. If the Valsalva LVOT gradient is < 20 mmHg, reduce the dose to 2.5 mg once daily. Otherwise, maintain the dose at 5 mg once daily. Subsequent follow-up visits should take place 8 and 12 weeks after starting treatment, with dose adjustments as needed.

This drug may lower left ventricular ejection fraction, increasing the risk of heart failure. Therefore, regular cardiac function assessments should be performed before starting this medication, and initiation should not occur if the left ventricular ejection fraction is below 55%. Additionally, if signs of heart failure occur or cardiac function worsens, the medication should be discontinued. This medicine should not be used in combination with other drugs that inhibit or induce certain liver enzymes, as this may increase the risk of heart failure. It should not be administered to pregnant women as it could harm the fetus, and women of childbearing potential should verify pregnancy status before use and employ effective contraception during treatment and for at least 4 months after discontinuation. Do not use this medication if hypersensitivity exists or if taking potent drugs that inhibit or induce certain enzymes, or if pregnant. Caution is needed for patients with severely reduced renal or liver function, and it is particularly not recommended for patients with severe liver dysfunction. This drug may further decrease cardiac contractility when used with beta-blockers or certain calcium channel blockers, so use with caution. Symptoms such as dizziness or headaches may occur during treatment, requiring caution when driving or operating machinery. Additionally, this medication can interact with various drugs, and all medications being taken must be disclosed to the physician, including over-the-counter medicines. In case of overdose, serious side effects such as decreased cardiac function may occur, and immediate medical assistance should be sought. Pregnant or breastfeeding women must consult with healthcare professionals regarding the use of this drug.

• Dizziness
• headache
• stress-induced cardiomyopathy
• syncope
• atrial fibrillation
• palpitations
• nasopharyngitis
• back pain
• cough
• shortness of breath

Store this medicine in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1°C and 30°C.

Appearance

This medicine is an opaque gray hard capsule with a white to off-white powder filled inside. The upper part is printed with '15 mg' and the lower part with 'Mava'.

Package unit

Blister - 28 capsules/box