Sildapa MR Tablets 5/50/1000 Milligrams

Adult dose

To minimize gastrointestinal adverse reactions due to metformin hydrochloride, this medication should be taken once daily with dinner. Take 2 tablets of this product 5/50/500mg, 5/50/750mg, and 5/50/1000mg once daily. In cases where adequate blood glucose control cannot be achieved with the combination therapy of metformin hydrochloride and sitagliptin, a starting dose of 10mg dapagliflozin and 100mg sitagliptin may be prescribed.

This medication contains three ingredients: sitagliptin, dapagliflozin, and metformin, each with specific precautions. First, sitagliptin can rarely cause serious allergic reactions, so if symptoms such as skin rash, difficulty breathing, or swelling of the face or lips occur, you should stop taking it immediately and consult a doctor. Additionally, acute pancreatitis may occur; thus, if symptoms like abdominal pain, vomiting, or fever arise, promptly inform medical personnel. Dapagliflozin may cause reduced body fluid volume and low blood pressure, so caution is advised if you are dehydrated or have a history of low blood pressure. The risk of genital infections and urinary tract infections may increase, so you should seek appropriate treatment if related symptoms appear. Moreover, a serious metabolic condition known as diabetic ketoacidosis may occur, so be alert for symptoms such as vomiting, abdominal pain, difficulty breathing, or fatigue. Rare but severe infections such as Fournier's gangrene have also been reported; immediate treatment is necessary if symptoms develop. Metformin may rarely cause a fatal side effect known as lactic acidosis, so it should not be used in patients with impaired kidney function or those suffering from severe infections, dehydration, liver disease, or congestive heart failure. If symptoms like nausea, vomiting, abdominal pain, muscle pain, or difficulty breathing occur while taking it, inform your doctor immediately. Also, gastrointestinal discomfort is common with metformin, so consult your doctor if this causes significant discomfort. This medication should not be administered to patients with poor kidney function, acute heart failure, severe infections, patients scheduled for surgery, or pregnant women. Regular kidney function tests should be conducted before and during treatment. As there is a risk of hypoglycemia, caution is advised when skipping meals or exercising excessively and when used in combination with other blood glucose-lowering medications; if hypoglycemic symptoms appear, take sweets immediately. It is advisable to avoid alcohol consumption while taking this medication, and regular blood tests are recommended as a deficiency of vitamin B12 may occur. Lastly, it is crucial to consult a doctor or pharmacist immediately if any adverse reactions or suspected symptoms appear to receive appropriate measures.

Serious side effects

Rash, severe swelling (edema), chest tightness, shortness of breath, cold sweat, paleness, anaphylaxis, angioedema, Stevens-Johnson syndrome, exfoliative skin disease, acute pancreatitis, fatal/non-fatal hemorrhagic or necrotizing pancreatitis, lactic acidosis, acute kidney failure, worsening renal function, liver abnormalities (jaundice), acute kidney failure, hemorrhagic pancreatitis, necrotizing pancreatitis, acute renal injury, renal impairment, severe allergic reactions, serious weakness

Mild side effects

• Hypoglycemia
• headache
• constipation
• nausea
• vomiting
• malaise
• diarrhea
• abdominal pain
• loss of appetite
• weight loss

This medication should be stored in a tightly closed container to protect it from moisture and air. It is best to maintain a storage temperature between 1 degree and 30 degrees Celsius. Proper storage will help preserve the effectiveness and safety of the medication.

Appearance

Yellow oval prolonged-release film-coated tablets

Package unit

30 tablets/bottle