Duvimet SR 0.25/50/1000 mg

Adult dose

The 0.5/100/1000 mg controlled-release tablets are taken once daily, one tablet at a time. Patients taking the 0.25/50/500 mg, 0.25/50/750 mg, or 0.25/50/1000 mg controlled-release tablets should take two tablets simultaneously once daily. This medication is typically administered once daily with the evening meal, with gradual dose escalation to reduce gastrointestinal side effects related to metformin.

This medication may cause or exacerbate heart failure in patients with cardiac dysfunction, so it should be administered under thorough medical supervision. If symptoms of heart failure such as sudden weight gain, shortness of breath, or swelling occur, consult a healthcare professional immediately. It is advisable not to use this medication in patients with severe heart failure. Additionally, this medication may cause fluid retention, increasing the risk of heart failure, so caution is necessary. Some components of this medication may trigger allergic reactions, so it should be avoided in patients with hypersensitivity. Acute pancreatitis, a serious inflammation of the pancreas, may rarely occur; thus, report any symptoms such as abdominal pain, nausea, or vomiting to a doctor immediately. This medication can rarely cause serious metabolic disorders called lactic acidosis; seek medical attention if sudden fatigue, muscle pain, shortness of breath, or abdominal pain occur. It is not safe to use this medication in patients with impaired kidney function or liver dysfunction. Temporary discontinuation of the medication may be necessary before and after surgery, or in cases of severe infections or dehydration. Regular blood tests and monitoring of kidney and liver function are required during treatment, and any symptoms of weight gain, swelling, or shortness of breath should be communicated to healthcare professionals immediately. Moreover, this medication poses a risk of hypoglycemia, so care should be taken with irregular meals, intense exercise, or concurrent use with other hypoglycemic medications. Women who are pregnant or planning to become pregnant should consult a doctor before starting this medication. Alcohol intake should be avoided while on this medication, and if a dose is missed, patients should be cautious not to double the dose the next day. The use of this medication may decrease vitamin B12 levels in the body, necessitating regular testing and supplementation if needed. This medication has been reported to cause side effects such as blurred vision, macular edema, and increased fracture risk in some patients; therefore, consult a doctor if there are any eye issues or concerns about bone health. If severe joint pain or skin blisters occur during use, consult healthcare professionals immediately. This medication can enhance blood sugar control effects when used with other diabetes medications; however, it may also increase the risk of hypoglycemia, so vigilance is advised. Finally, strict dietary management and blood sugar monitoring should be adhered to, and any abnormal symptoms should be reported to a specialist immediately.

Serious side effects

Urticaria, severe swelling (edema), symptoms and signs of heart failure (excessive and rapid weight change, shortness of breath, edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions (anaphylaxis, angioedema), Stevens-Johnson syndrome, severe skin adverse reactions (severe rash, blisters, skin peeling, pain in oral/ocular mucosa), acute pancreatitis, lactic acidosis, liver abnormalities (jaundice), profound lethargy, sudden

Mild side effects

• Headache
• indigestion
• constipation
• diarrhea
• itching
• tinnitus
• dizziness
• upper respiratory infection
• nasopharyngitis
• cough

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The ambient temperature should be maintained between 1 and 30 degrees Celsius. This will help to preserve the effectiveness of the medication for a longer time and ensure safe usage.

Appearance

Blue, biconvex, oval-shaped controlled-release film-coated tablet

Package unit

30 tablets/bottle