Clozartan Tablets 50/6.25 mg (Losartan, Chlorthalidone)

Adult dose

The recommended dosage for this medication is 1 tablet once daily, taken with water regardless of meals. It is advised to take it at the same time every day (e.g., morning). If blood pressure is not controlled with monotherapy of losartan potassium, doses of 50/6.25 mg or 50/12.5 mg, and 100/12.5 mg can be administered. For elderly patients (75 years or older), a starting dose of 25 mg of losartan potassium should be administered as this medication.

This medication may cause serious harm to the fetus and newborn during pregnancy, so it should be discontinued immediately upon confirmation of pregnancy. Patients with impaired liver function or ongoing liver disease may experience severe side effects, such as hepatic encephalopathy, while taking this medication, so caution is advised. Patients with severe kidney disease may be at risk for increased blood urea nitrogen and worsening kidney function, so this medication should be avoided or used with caution. Patients with a known allergy to the ingredients of this medication or similar medications, as well as pregnant or breastfeeding women, and those with severe liver dysfunction or renal failure should not take this medication. Patients with a history of angioedema or certain heart diseases, electrolyte abnormalities, gout, Addison's disease, or those undergoing lithium therapy should also avoid this medication. Elderly patients or those at risk of electrolyte imbalance should be closely monitored for blood pressure and electrolyte status during administration, and patients with mildly impaired liver function should use this medication cautiously. This medication may have a potent hypotensive effect, so patients with heart or vascular diseases should be cautious of complications due to excessive blood pressure lowering. During administration, adverse reactions such as dizziness, headache, dyspepsia, skin rash may occur, and in severe cases, consult a doctor immediately. When used in combination with other antihypertensives, diuretics, potassium-sparing diuretics, lithium, non-steroidal anti-inflammatory drugs, the risk of adverse effects may increase due to interactions, so follow expert guidance for use. Pregnant or nursing women should not take this medication, and if it must be taken, breastfeeding should be discontinued. Safety and efficacy in children have not been established and are not recommended. Overdose may lead to hypotension, tachycardia, electrolyte imbalance, necessitating immediate medical attention. This medication should be stored out of reach of children and should not be transferred to other containers.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, breathlessness or difficulty breathing, asthma attacks, cough with fever and respiratory irregularities, yellowing of the skin or eyes (jaundice), severe lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urinary issues

Mild side effects

• Dizziness
• headache
• abdominal distension
• chronic gastritis
• dyspepsia
• upper abdominal pain
• gastroesophageal reflux disease
• weakness
• enterocolitis
• herpes zoster

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/bottle