Sitagliptin and Metformin Film-Coated Tablets 50/500 mg (Sitagliptin Hydrochloride Hydrate, Metformin Hydrochloride)

Adult dose

This medication is generally taken twice daily with food, and the dosage is gradually increased to reduce gastrointestinal adverse reactions caused by metformin. 1. Patients not currently receiving treatment with metformin: Take this medication 50/500 mg twice daily, 1 tablet at a time, and it can be increased to 50/1000 mg twice daily, 1 tablet at a time. 2. Patients currently treated with metformin: Sitagliptin

This medication consists of two components, each playing a role in aiding blood glucose control. Firstly, this medication may cause allergic reactions, so if symptoms such as skin rash, hives, or difficulty breathing occur, use should be stopped immediately and a doctor consulted. Additionally, this medication may cause serious side effects such as pancreatitis, which is inflammation of the pancreas, so if symptoms such as abdominal pain, vomiting, or loss of appetite occur, a doctor should be notified promptly. One of the components of this medication may be risky for patients with impaired kidney function, so it should not be used if kidney function is decreased, and regular kidney function assessments should be conducted. Furthermore, patients with severe infections, dehydration, heart failure, or acute myocardial infarction should also not use this medication, and administration should be stopped for a certain period before and after surgery. It is safe not to use this medication during pregnancy or breastfeeding. This medication can cause hypoglycemia, so when used in conjunction with other blood glucose lowering agents, blood glucose levels should be monitored closely, and immediate action should be taken if symptoms arise. During treatment, it is advisable to avoid alcohol consumption, as excessive drinking can increase the risk of serious side effects. This medication can cause side effects such as gastrointestinal disturbances, diarrhea, nausea, and vomiting, so attention should be paid to these symptoms during administration. Additionally, this medication contains certain pigment components, so extra caution is needed if there is an allergy to that component. Regular blood tests and kidney function tests should be performed while taking this medication, and vitamin B12 levels may decrease, so supplementation may be needed if required. Finally, patients taking this medication should consult a doctor immediately if symptoms such as sudden muscle pain, joint pain, or skin blisters occur.

Serious side effects

Hives, severe swelling (angioedema), difficulty breathing, anaphylaxis, severe skin reactions (rash, skin peeling, pain in oral/ocular mucosa, Stevens-Johnson syndrome, blistering dermatitis), acute pancreatitis, acute renal failure, respiratory problems (dyspnea), liver problems (jaundice), severe neurological symptoms (headache, seizures, confusion, visual disturbances, paralysis), severe edema, hypoxia, acute angina, severe joint pain,

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container that is not exposed to air, and it is safe to keep it at room temperature between 1°C and 30°C. Storing it this way helps maintain the effectiveness of the medication for a longer time.

Appearance

Bright pink oval film-coated tablet

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle