Sitagliptin Duo Tablet 50/500 mg

Adult dose

This medication is generally taken twice daily with food, with gradual dose increasing to reduce gastrointestinal side effects caused by metformin. 1. Patients currently not treated with metformin: - Take this medication 50/500 mg twice daily, one tablet per dose, and the dosage can be increased to 50/1000 mg twice daily, one tablet per dose. 2. Patients undergoing treatment with metformin: - The recommended initial dosage of this medication for patients who cannot achieve adequate blood sugar control with metformin alone is 50 mg of sitagliptin twice daily (total of 100 mg per day) along with the previously administered dosage of metformin.

This medication contains two components, sitagliptin and metformin, and is used for diabetes treatment. When taking this medication, serious allergic reactions may occur. If you experience symptoms such as rash or difficulty breathing, you should immediately stop taking the medication and consult a doctor. Additionally, pancreatitis, an inflammation of the pancreas, may occur, so if you experience abdominal pain, vomiting, or loss of appetite, you should promptly inform a healthcare professional. Due to the metformin component, lactic acidosis, a rare but fatal metabolic disorder, can occur; therefore, this medication should not be taken during severe infections, dehydration, or when there is reduced kidney function. Patients with moderate to severe renal impairment, acute heart failure, or those scheduled for certain imaging tests should not take this medication, and pregnant or nursing women should also avoid it. Care should be taken when experiencing irregular meals, vigorous exercise, or taking other medications together as there may be risks of hypoglycemia or other side effects. Common side effects include diarrhea, nausea, headache, upper respiratory infection, and especially when taken with insulin or sulfonylureas, the risk of hypoglycemia may increase. Blood sugar levels, kidney function, and vitamin B12 levels should be regularly monitored, and if any unusual symptoms arise, you should consult a doctor immediately. Before and after surgery, this medication should be discontinued for a while, and alcohol consumption should be avoided as it can increase the risk of lactic acidosis. This drug can be given to the elderly but careful monitoring of kidney function is necessary, and in case of overdose, you should seek medical attention immediately for appropriate treatment.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, chest tightness, difficulty breathing, rash, severe skin reactions (including Stevens-Johnson syndrome, exfoliative skin disease), severe rash with high fever, blisters, skin peeling, oral/eye mucosal pain, acute pancreatitis, acute renal failure, liver dysfunction (elevated liver enzyme levels, potential jaundice), sudden and severe headache, seizures, altered consciousness, visual disturbances, paralysis

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• headache
• upper respiratory infection
• nasopharyngitis
• constipation
• weakness
• muscle pain

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. Additionally, it is best to keep the drug at room temperature between 1 to 30 degrees Celsius, not in excessively hot or cold places.

Appearance

Light pink oval film-coated tablet

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle