Janugriptin Duo XR Sustained Release Tablet 50/1000 mg

Adult dose

The dosage is determined based on each patient's current treatment regimen, efficacy, and tolerability without exceeding the maximum daily recommended dosage of 100 mg of sitagliptin and 2000 mg of metformin. This medication should be taken once daily with meals, primarily in the evening, while gradually increasing the dosage. The sustained release tablet should be swallowed whole and not split, crushed, chewed, or broken. For 100/1000 mg sustained release tablets, take once daily, 1 tablet at a time. For 50/50

This medication is used for the treatment of diabetes and assists in blood sugar control. However, it may cause allergic reactions in some patients, so if symptoms such as a skin rash, difficulty breathing, or swelling of the face or throat occur within three months after starting the medication, it should be discontinued immediately and a doctor consulted. There is a risk of pancreatitis, an inflammation of the pancreas, with this medication, so patients should notify their healthcare provider immediately if abdominal pain, vomiting, or severe abdominal discomfort occur. Additionally, one of the components in this medication should not be administered to patients with severely impaired kidney function, and patients with reduced kidney function should undergo regular kidney function tests. Acute diseases that can affect kidney function, such as severe infections, dehydration, acute heart failure, and acute myocardial infarction, should not be treated with this medication. In particular, the medication should be temporarily discontinued before and after examinations using iodine contrast media, and reinitiated only after confirming normal kidney function. Women who are pregnant or may become pregnant, as well as nursing mothers, should avoid taking this medication for safety. This medication can cause hypoglycemia, so caution should be exercised when skipping meals or engaging in vigorous exercise, and the dosage should be adjusted under the direction of a physician if taken with other hypoglycemic agents to reduce the risk of hypoglycemia. Moreover, this medication may lower vitamin B12 levels, so regular blood tests to check vitamin B12 levels are recommended for long-term use. Excessive alcohol consumption can increase the risk of side effects from this medication, thus alcohol should be avoided during treatment. If surgery is planned, this medication should be discontinued 48 hours prior to the procedure, and resumed once normal oral intake has returned and kidney function has been confirmed to be normal. While taking this medication, regular blood sugar tests and kidney function checks should be conducted to continuously monitor health status, and any unusual symptoms should prompt immediate consultation with a physician.

Serious side effects

Urticaria, severe swelling (edema), anaphylaxis, exfoliative skin disease (including Stevens-Johnson syndrome), acute pancreatitis, severe lactic acidosis, angioedema, rash, cutaneous vasculitis, acute renal failure, severe hypoglycemia, bullous pemphigoid, elevated liver enzymes, acute and non-fatal hemorrhagic or necrotizing pancreatitis, acute pancreatitis, severe and incapacitating arthralgia, bullous pemphigoid, rhabdomyolysis

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• constipation
• nasopharyngitis
• myalgia
• limb pain

This medication is sensitive to air and moisture, so to ensure safe storage, it should be kept in a sealed container. It is advisable to store it at room temperature between 1 and 30 degrees Celsius. This will help maintain its efficacy and prevent degradation.

Appearance

Bright green oval sustained release film-coated tablets

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle