JanuaTin Duo Extended Release Tablet 100/1000 mg

Adult dose

This 100/1000 mg extended-release tablet is taken once a day, one tablet at a time. Patients taking the 50/500 mg or 50/1000 mg extended-release tablets should take two tablets at a time, once daily. 1. For patients not currently treated with metformin: The initial dosage is a total daily of sitagliptin 100 mg and metformin 1000 mg, which may be adjusted as necessary.

This medication is composed of two ingredients, sitagliptin and metformin, and is primarily used for blood sugar control in patients with type 2 diabetes. Severe allergic reactions may occur while taking this medication, so if skin rashes, hives, or difficulty breathing occur, discontinue use immediately and consult healthcare professionals. There is a risk of developing pancreatitis, which is inflammation of the pancreas; therefore, if symptoms such as abdominal pain, vomiting, or loss of appetite arise, it is crucial to visit a hospital promptly. This medication should not be used in patients with severely impaired kidney function or in states of severe infection, dehydration, or heart failure, and it should also be discontinued before and after tests using iodine contrast agents. It is safe for women who are pregnant or may become pregnant, as well as for breastfeeding mothers, to avoid taking this medication. During use, irregular meals, excessive exercise, and co-administration with specific medications may lead to serious side effects such as hypoglycemia or lactic acidosis, so caution is necessary. In particular, the metformin component can cause rare but fatal metabolic complications known as lactic acidosis, so it is essential to have regular kidney and liver function tests and to inform healthcare providers immediately of any unusual symptoms. Furthermore, this medication can reduce vitamin B12 levels in some patients, so if used for a long time, monitoring through blood tests is necessary. Alcohol consumption may increase the risk of side effects from this medication, so excessive drinking should be avoided during treatment. Temporary discontinuation of use may be needed during surgery or acute illnesses, resuming only after the patient's condition stabilizes. It is essential to continue treatment safely through regular blood glucose tests and kidney function checks while using this medication.

Serious side effects

Severe allergic reactions such as hives, anaphylaxis, angioedema, Stevens-Johnson syndrome; acute pancreatitis including fatal/non-fatal hemorrhagic or necrotizing pancreatitis; deterioration of kidney function including acute renal failure (sometimes requiring dialysis); severe and debilitating arthralgia; blistering mucous membrane conditions; severe lactic acidosis; hypoglycemia (including severe cases with consciousness disturbances, seizures, etc.)

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• myalgia
• limb pain

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. Additionally, it should be stored at room temperature between 1 to 30 degrees Celsius to maintain its effectiveness.

Appearance

Bright blue, double convex, oval-shaped extended-release film-coated tablet

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle