Janudim Extended-release Tablet 50/1000 mg

Adult dose

This medication 100/1000 mg extended-release tablet is taken once daily at a dose of 1 tablet. Patients who are taking the 50/500 mg extended-release tablets or the 50/1000 mg extended-release tablets should take 2 tablets simultaneously once daily. 1. For patients who are not currently being treated with Metformin: The initial dose is a total daily dose of 100 mg Sitagliptin and 1000 mg Metformin. If the initial dose is insufficient for adequate blood sugar control, the dosage can be gradually increased to the maximum recommended daily dose of 2000 mg for Metformin while monitoring for gastrointestinal side effects. 2. For patients currently being treated with Metformin: The recommended initial dose of this medication is a total daily dose of Sitagliptin 100 mg and the existing Metformin dosage for those unable to control blood sugar adequately on Metformin monotherapy.

This medication contains both Sitagliptin and Metformin, helping to control blood sugar. Firstly, it may cause serious allergic reactions in some patients, so if symptoms such as rash, hives, or difficulty breathing occur, the medication should be discontinued immediately, and a doctor should be consulted. Also, acute pancreatitis, an inflammation of the pancreas may occur, so symptoms such as abdominal pain, nausea, and vomiting should be closely monitored and reported to a doctor. The Metformin component included in this medication can rarely lead to a serious metabolic disorder known as lactic acidosis, which may present with symptoms such as muscle pain, weakness, difficulty breathing, and abdominal pain; these symptoms should prompt immediate notification to healthcare staff. Patients with poor kidney function, severe infections, or dehydration, and those with acute myocardial infarction or heart failure should not use this medication as it may pose risks. In addition, the use of iodine contrast agents before and after scans may worsen kidney function and pose a risk of lactic acidosis, so use of this drug should be temporarily halted, resuming only after confirming normal kidney function post-scan. Women who are pregnant or breastfeeding are advised against using this medication, and safety has not been established for children under the age of 18. This medication may increase the risk of hypoglycemia due to irregular meals, intense exercise, or interactions with other medications, thus careful monitoring of blood sugar changes is necessary. Furthermore, long-term use may lower vitamin B12 levels, so regular blood tests are recommended, and alcohol intake should be avoided due to the risk of lactic acidosis. Patients scheduled for surgery should discontinue this medication 48 hours before surgery and resume only after normal oral intake and confirmation of kidney function. Finally, regular monitoring of blood sugar, kidney function, and hematological tests should be conducted while taking this medication, and any unusual symptoms should be promptly discussed with healthcare staff.

Serious side effects

Hives, angioedema, chest discomfort, difficulty breathing, cold sweats, pallor, anaphylaxis, severe skin adverse reactions (including Stevens-Johnson syndrome, exfoliative skin disease), acute pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing pancreatitis), acute renal failure, jaundice (yellowing of skin or eyes), generalized fatigue, severe headache, seizures, confusion, visual disturbances, paralysis, severe swelling, significant reduction in urine output

Mild side effects

Diarrhea, nausea, vomiting, abdominal pain, upper respiratory tract infection, nasopharyngitis, headache, arthralgia, myalgia, limb pain, back pain, interstitial lung disease, pruritus, thrombocytopenia, rhabdomyolysis, hypoglycemia, decreased vitamin B12, joint pain without severe or disabling symptoms

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is essential to maintain a storage temperature between 1 and 30 degrees Celsius. This helps to preserve the effectiveness and safety of the medication for an extended period.

Appearance

Bright green oval-shaped extended-release film-coated tablet

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle