Sidiphen Extended Release Tablet 50/1000 mg

Adult dose

The 100/1000 mg extended-release tablet should be taken once daily, with one tablet at a time. Patients taking the 50/500 mg extended-release tablet or the 50/1000 mg extended-release tablet should take two tablets at a time once daily. 1. For patients not currently treated with metformin: The initial dosage is a total daily amount of sitagliptin 100 mg and metformin 1000 mg. If necessary, metformin dosage can be adjusted to a maximum daily limit.

This medication consists of two components, sitagliptin and metformin, both of which are used in diabetes treatment. Firstly, sitagliptin can cause rare but severe allergic reactions, so if symptoms such as hives, rash, or difficulty breathing occur, use should be stopped immediately. Additionally, there is a risk of acute pancreatitis, which can cause inflammation of the pancreas, so careful monitoring is required if severe abdominal pain or vomiting occurs, and medication should be discontinued if necessary. Metformin can cause a rare complication called lactic acidosis, which is very dangerous and can be accompanied by symptoms such as muscle pain, difficulty breathing, fatigue, and abdominal pain. Especially patients with reduced kidney function, liver dysfunction, severe infection, or dehydration should not take this medication. This drug should not be administered to patients with severe kidney impairment, acute heart failure, acute myocardial infarction, or to pregnant or breastfeeding women. Moreover, during the use of this medication, regular meals and appropriate exercise should be maintained, as sudden decreases in meal size or intense exercise can increase the risk of hypoglycemia. There is an increased risk of hypoglycemia when this medication is used in combination with other blood glucose-lowering agents, so dosage adjustment may be necessary when taken with insulin or sulfonylureas. Gastrointestinal side effects such as diarrhea, nausea, vomiting, headache may occur during use; if symptoms are severe or persistent, consultation with a healthcare professional is recommended. Regular monitoring of liver and kidney functions is necessary, particularly for elderly patients or those with weak kidney function. Before and after surgery, this medication should be discontinued for a period of time, and it should only be resumed after the postoperative condition stabilizes and kidney function is confirmed to be normal. Lastly, excessive alcohol consumption should be avoided during this medication period, as alcohol can increase the risk of lactic acidosis, a side effect of this drug. If any abnormal symptoms or discomfort arise during the use of this drug, it is important to inform a healthcare professional immediately and receive appropriate care.

Serious side effects

• Urticaria
• angioedema
• anaphylaxis
• exfoliative skin disease
• Stevens-Johnson syndrome
• acute pancreatitis
• lactic acidosis
• acute renal failure
• severe and debilitating arthralgia
• bullous pemphigoid

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• constipation
• vomiting
• headache
• arthralgia
• myalgia
• limb pain
• back pain
• interstitial lung disease

This medication is sensitive to air and moisture, so it should be stored in a sealed container. It is best to maintain the storage temperature between 1 and 30 degrees Celsius at room temperature. This helps to preserve the effectiveness of the medication for a longer period.

Appearance

Bright green oval extended-release film-coated tablet

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle