Dapalcita Tablet 10/100mg (Dapagliflozin, Sitagliptin)

Adult dosage

Patients taking sitagliptin 100 mg and dapagliflozin 10 mg may take 1 tablet once daily with or without meals. The tablet should be swallowed whole.

This medication is a diabetes treatment combining two active ingredients that assist in blood sugar control. The first ingredient inhibits glucose reabsorption in the kidneys, increasing glucose excretion in the urine, resulting in lower blood sugar levels. However, this process can reduce body fluid levels, which may lower blood pressure, thus patients with dehydration or low blood pressure should exercise caution. Additionally, this ingredient can increase the risk of kidney damage in patients with reduced kidney function or the elderly, so kidney function should be carefully monitored before and after administration. If symptoms of reduced fluid volume occur, discontinuation of the medication may be necessary, and there is also a risk of developing a serious metabolic disorder known as diabetic ketoacidosis, so patients should consult healthcare professionals immediately if symptoms occur. The second ingredient stimulates insulin secretion and helps control blood sugar. This ingredient may cause allergic reactions, or rarely, severe pancreatitis in some patients, so patients should notify their doctors immediately if they experience skin rashes or abdominal pain. This medication may increase the risk of hypoglycemia, so when taken with other glucose-lowering agents such as insulin or sulfonylureas, blood sugar levels should be closely monitored, and dosage adjustments may be necessary. This medication is not to be used in specific patients, such as those allergic to the components or patients with type 1 diabetes or those undergoing dialysis. It is recommended that pregnant or lactating women avoid using this medication, especially during breastfeeding, as it may affect the infant. While taking this medication, the possibility of infections, particularly genital and urinary tract infections, may arise, so prompt treatment should be sought upon the appearance of related symptoms. Elderly patients or those with decreased kidney function have a higher risk of adverse effects while on this medication, hence regular health checks are necessary. Finally, care should be taken when driving or operating machinery during treatment, as the risk of accidents due to hypoglycemia exists.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, paleness, anaphylaxis, angioedema, Stevens-Johnson syndrome, exfoliative skin disease, acute pancreatitis, hemorrhagic pancreatitis, necrotizing pancreatitis, severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, shortness of breath or breathing difficulty, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice)

Mild side effects

• Vulvitis
• balanitis
• fungal infections
• urinary tract infections
• hypoglycemia
• thirst
• dizziness
• constipation
• dry mouth
• back pain

This medication may be sensitive to air or moisture, so it should be stored in a tightly closed container. The storage temperature should ideally be maintained at room temperature between 1 degree and 30 degrees Celsius. This will help to preserve the effectiveness and safety of the medication over time.

Appearance

Beige oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]