Posiromet Extended-Release Tablets 10/1000 mg (Dapagliflozin, Metformin)

Adult dose

The dosage of this medication should be individualized based on the patient's current treatment, efficacy, and tolerability, without exceeding the maximum recommended dosages of dapagliflozin 10 mg and extended-release metformin 2000 mg. This medication is typically administered once daily with the evening meal. The maximum dosage of this medication is once daily dapagliflozin 10 mg/extended-release metformin 2000 mg and can be prescribed as two tablets of 5 mg/1000 mg.

This medication is used for diabetes treatment, and the two active ingredients work together to control blood sugar. During the use of this medication, serious metabolic complications such as lactic acidosis may rarely occur, so if symptoms or abnormalities appear, consult a physician immediately. Caution is required when using it in combination with insulin or other blood sugar-lowering agents due to the risk of hypoglycemia. Patients with severely impaired renal function, dehydration, serious infections, heart problems, etc., should not use this medication. Before and after surgery or administration of radiographic contrast agents, the medication should be discontinued for a certain period and restarted only after confirming normal kidney function. Pregnant or nursing women should not use this medication. Elderly patients or those with impaired renal function should regularly test kidney function before and after taking this medication, and dosage adjustments may be necessary if needed. This medication can increase the risk of genital and urinary infections; hence immediate treatment should be sought if symptoms of infection appear. Also, signs of reduced fluid volume or hypotension may occur, so care must be taken to prevent dehydration, and any symptoms should be reported to a physician. This medication may lower vitamin B12 levels; therefore, routine checks of vitamin B12 levels are advised for long-term use. Alcohol consumption may increase the risk of lactic acidosis, so excessive drinking should be avoided. Patients should consult healthcare professionals immediately if blood sugar control fails or abnormal symptoms arise while taking this medication, and attention should be paid to symptoms of hypoglycemia. This medication may interact with specific drugs, so any concomitant medications must be reported to a physician or pharmacist. It is preferable not to use this medication in children, pregnant women, or nursing mothers since its safety is not established. In case of overdose, seek medical treatment immediately, and this medication should be kept out of reach of children.

Serious side effects

Lactic acidosis, severe hypoglycemia, severe edema accompanied by hypertension, diabetic ketoacidosis, acute kidney injury, renal impairment, urosepsis, pyelonephritis, perineal necrosis, acute cholecystitis, Guillain-Barré syndrome, atrial fibrillation, chest pain, headache (if classified as severe neurological symptoms), chest tightness, difficulty breathing, asthma attacks, cold sweat, pallor, skin peeling, severe rashes with high fever, blisters, mouth/eye symptoms

Mild side effects

• Vulvitis
• balanitis and related genital infections
• urinary tract infections
• fungal infections
• hypoglycemia
• dry mouth
• dizziness
• constipation
• low back pain
• dysuria

This medication should be stored in a tightly sealed container to prevent air and moisture exposure, preferably at room temperature between 1 degree and 30 degrees Celsius. This way, the effectiveness of the medication can be maintained for a longer duration.

Appearance

Yellow, bi-convex, oval-shaped extended-release film-coated tablets

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle