Preda Tablets 2 mg (Estradiol Monohydrate)

Adult dosage

As estradiol, administer 1 or 2 mg orally once daily without interruption. If adverse reactions occur with 2 mg, reduce to 1 mg. Women who have undergone hysterectomy and postmenopausal women may start on any convenient day. If menstruating normally, administration should begin on the 5th day of the menstrual cycle, implementing estrogen-progestogen combination therapy.

This drug may increase the risk of endometrial cancer and endometrial hyperplasia in women after menopause; therefore, women with an intact uterus must take progestogens as prescribed by a physician and undergo regular check-ups. Long-term use may slightly increase the risk of breast cancer, so regular breast examinations are necessary, and any unusual symptoms in the breast should be reported to a doctor immediately. Patients with breast cancer or metastatic diseases should discontinue this medication, as it may elevate blood calcium levels, and seek appropriate treatment. Patients with or suspected of having certain conditions such as breast cancer, endometrial cancer, liver disease, thrombosis, cardiovascular disease, and those who are pregnant should not take this medication. In cases of personal or family history of thrombosis, hypertension, diabetes, liver disease, headache, asthma, or depression, closer monitoring is required while taking this medication. While taking this medication, side effects such as abdominal pain, breast pain, edema, headache, and rash may occur; if symptoms are severe or persist, consult a doctor. This medication can affect blood clotting; hence, it should be temporarily discontinued before and after surgery. If sudden leg swelling, chest pain, or difficulty breathing occurs, seek medical attention immediately. This medication is not administered to women who are pregnant or breastfeeding, and caution should be taken to avoid pregnancy while taking this medication if pregnancy is possible. There may be interactions with other medications; hence, it is crucial to inform healthcare providers if on antiepileptics, antibiotics, diabetes medications, etc. Regular checks for blood pressure, breast, and liver function must be conducted before and during use, and report any unusual symptoms to a doctor immediately. This medication is not a contraceptive, so separate contraceptive methods should be employed to prevent pregnancy. Store this medication at room temperature below 25 degrees and keep it out of reach of children; it is safer to store it in its original container.

Serious side effects

• Urticaria
• edema
• venous thrombosis
• breast cancer
• endometrial cancer
• jaundice
• significant increase in hypertension
• migraine headaches
• pregnancy
• sudden visual impairment

Mild side effects

• Breast tenderness
• breast pain
• abdominal pain
• headache
• visual disturbances
• dyspepsia
• vomiting
• bloating
• abdominal distension
• gallstones

This medication should be stored in a tightly sealed container with good air circulation and must be kept from freezing. Additionally, it is advisable to store it in a cool, dry place away from light at temperatures below 25 degrees.

Appearance

Blue round film-coated tablet

Package unit

30 tablets/PTP, 28 tablets/PTP