Penmix Sitagliptin Tablets (Sitagliptin Phosphate Monohydrate · Dapagliflozin Propanediol Monohydrate)

Adult dosage

For patients receiving sitagliptin 100 mg and dapagliflozin 10 mg, one tablet may be administered once daily regardless of meals. The tablet should be swallowed whole.

This medication contains sitagliptin phosphate monohydrate and dapagliflozin propanediol monohydrate. First, the sitagliptin component can rarely cause severe allergic reactions; therefore, if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur within three months of starting treatment, usage should be immediately stopped and a healthcare professional consulted. Additionally, sitagliptin can cause acute pancreatitis, an inflammation of the pancreas, so if symptoms such as abdominal pain, nausea, or vomiting occur, healthcare professionals should be notified immediately. This medication should not be used in patients with type 1 diabetes, diabetic ketoacidosis, or those undergoing dialysis. The dapagliflozin component may cause low blood pressure or impaired kidney function due to decreased body fluid levels. Therefore, patients with poor kidney function, elderly patients, and those on diuretics should carefully check their kidney function and fluid status before administration, and periodically monitor blood pressure and kidney function during treatment. This medication may increase the risk of genital and urinary infections; if symptoms of infection, such as itching, pain, or increased discharge, occur, consult a doctor immediately. Moreover, serious metabolic imbalances known as diabetic ketoacidosis may arise, so if symptoms such as vomiting, abdominal pain, difficulty breathing, or fatigue occur, immediate medical attention is required. This medication is not recommended for use during pregnancy, and should be immediately discontinued if pregnancy is confirmed. It is also advisable for breastfeeding women not to use this medication. Safety and efficacy in children under 18 have not been established, so it should not be used in this population. While taking this medication, there is a risk of hypoglycemia when used in conjunction with insulin or sulfonylureas, so patients should be vigilant for signs of low blood sugar and adjust the doses of those medications if necessary. In case of overdose, visit a medical institution immediately for appropriate treatment, and dialysis may be somewhat helpful. Finally, while this medication does not significantly affect driving or machine operation, caution should be taken due to the possible occurrence of hypoglycemia.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, acute pancreatitis, pancreatitis, Stevens-Johnson syndrome, bullous pemphigoid, acute renal failure, deterioration of kidney function, necrotizing fasciitis (Fournier's gangrene), acute kidney injury, urinary sepsis, and pyelonephritis, severe hypoglycemia, diabetic ketoacidosis, severe allergic reactions, severe skin adverse reactions, respiratory problems, liver abnormalities (jaundice), neurological symptoms, severe edema or abdominal swelling.

Mild side effects

• Vulvovaginitis
• balanitis and related genital infections
• urinary tract infections
• fungal infections
• dry mouth
• dizziness
• constipation
• dry mouth
• low back pain
• dysuria

This medication should be stored in a tightly sealed container to protect it from air and moisture, ideally at room temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness for a longer period.

Appearance

Beige oval film-coated tablet

Package unit

30 tablets/PTP [10 tablets/PTP x 3]