Dapagliflozin/ Sitagliptin Tablets 10/100 mg

Adult dosage

For patients receiving sitagliptin 100 mg and dapagliflozin 10 mg, one tablet may be taken once daily regardless of meals. The tablet should be swallowed whole.

This medication contains two ingredients: sitagliptin and dapagliflozin. First, sitagliptin can rarely cause serious allergic reactions, so if symptoms such as rash, difficulty breathing, or swelling of the face or lips occur, discontinue use immediately and consult a doctor. Sitagliptin can also cause acute pancreatitis, a condition where inflammation occurs in the pancreas; thus, if symptoms such as abdominal pain, vomiting, or nausea arise, careful observation is necessary, and medical attention should be sought. Next, dapagliflozin may lead to lower blood pressure or worsen kidney function in patients with impaired kidney function or fluid depletion, so it is essential to routinely monitor blood pressure and kidney function before and during administration. This medication can also increase the risk of genital infections and urinary tract infections, so prompt treatment is required if symptoms of infection appear. Dapagliflozin can cause severe metabolic acidosis known as ketoacidosis, which can occur even if blood sugar is not high; symptoms may include nausea, vomiting, abdominal pain, fatigue, and difficulty breathing. Inform healthcare professionals immediately if these symptoms occur. This medication should not be used in patients with type 1 diabetes, those with diabetic ketoacidosis, or patients on dialysis, and should not be administered to patients with hypersensitivity to the drug or its excipients. Elderly patients or those with reduced kidney function should use this medication with particular caution, and adjustments in dosage may be necessary if used with other blood sugar-lowering agents like insulin or sulfonylureas due to the risk of hypoglycemia. Pregnant or breastfeeding women are advised not to use this medication, and if pregnancy is confirmed, it should be discontinued immediately. In the case of overdose, there is no specific antidote, and appropriate treatment should be provided based on symptoms, although some ingredients may be removed by dialysis. Finally, while taking this medication, caution should be exercised regarding hypoglycemic symptoms when driving or operating machinery, and it should be kept out of reach of children.

Serious side effects

• Hives
• severe swelling (edema)
• anaphylaxis
• angioedema
• severe hypersensitivity reactions
• Stevens-Johnson syndrome
• exfoliative skin disorders
• acute pancreatitis
• fatal hemorrhagic pancreatitis
• necrotizing pancreatitis

Mild side effects

• Headache
• upper respiratory infection
• rhinitis
• constipation
• vomiting
• dizziness
• weight loss
• thirst
• back pain
• pain during urination

This medication is sensitive to air and moisture, so it must be stored in a tightly closed container. It is important to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Beige oval film-coated tablets

Package unit

30 tablets/PTP [10 tablets/PTP x 3]