DURAB Tablet 60/2.5 mg (Pimasartan potassium, Esamlodipine)

Adult dose

The recommended dosage for adults is 1 tablet once a day, to be taken with water regardless of meals. It is advisable to take it at the same time each day (e.g., in the morning). If blood pressure is not controlled with Pimasartan monotherapy, you may administer 30/2.5 mg, 60/2.5 mg, or 60/5 mg formulations depending on the dosage. Elderly patients (under 70 years old) do not require initial dosage adjustment. Mild to moderate doses are recommended.

Child dose

The safety and efficacy in children and adolescents under 18 years have not been established.

This medicine can cause serious harm to the fetus and newborn when taken during pregnancy, especially in the second and third trimesters, so you should stop taking it immediately once pregnancy is confirmed. Patients who have an allergy to any component of this medication or those with certain kidney and liver diseases, bile duct obstruction, or severe aortic stenosis should not use this medicine. Patients with reduced blood volume or sodium deficiency, impaired kidney function, renal artery hypertension, etc., should be closely monitored while taking this medicine, as there may be occurrences of hypotension or worsening kidney function. While taking this medicine, side effects such as dizziness, headache, facial or peripheral edema, urinary disturbances, insomnia, and flushing may occur. If symptoms are severe or persistent, you should consult a healthcare professional. It is important to regularly check blood pressure and potassium levels as there is a risk of hypotension and electrolyte imbalances, particularly hyperkalemia. This medicine may interact with other antihypertensive agents, diuretics, potassium-sparing diuretics, potassium supplements, etc., so inform your healthcare provider of any other medications you are taking. Pregnant or breastfeeding individuals should consult a healthcare professional before taking this medicine, and if breastfeeding, they are advised to stop breastfeeding or discontinue the medicine. The safety and efficacy in children and adolescents under 18 years old have not been established, thus its use is not recommended. Elderly patients may react more sensitively to this medicine, so caution is needed during administration. In cases of overdose, severe hypotension, palpitations, and shock may occur; immediate medical attention is required.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, difficulty breathing or feeling short of breath, asthma attacks, respiratory distress accompanied by cough and fever, jaundice of the skin or eyes, severe fatigue throughout the body, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination.

Mild side effects

• Dizziness
• orthostatic dizziness
• headache
• facial edema
• peripheral edema
• urinary disturbances
• insomnia
• flushing
• dyspepsia
• vomiting

This medicine is sensitive to light, so it should be stored in a container that protects it from light. Additionally, it is important to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

Yellow, round-edged square film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle