Trusitam Extended-Release Tablet 50/750 mg (Sitagliptin, Metformin)

Adult dose

The dosage of this medication is determined by each patient's current treatment regimen, effectiveness, and tolerance, while staying within the maximum recommended daily dose for each ingredient: sitagliptin 100 mg and metformin 2000 mg. This medication is taken once daily in the evening with a meal to reduce gastrointestinal adverse reactions associated with metformin, and the dosage should be gradually increased. To maintain the extended-release characteristics, the tablets should not be divided, crushed, or chewed.

This medication is used in diabetes treatment and contains two active ingredients. The first ingredient is sitagliptin, which can rarely cause allergic reactions or serious skin conditions, including pancreatitis; therefore, discontinuation should occur immediately if symptoms appear, and a doctor should be consulted. The second ingredient is metformin, which should not be administered to patients with poor kidney function or certain acute conditions. There is a risk of lactic acidosis, a rare side effect associated with this medication, which can be life-threatening, so symptoms should be reported to healthcare professionals immediately. This medication should not be used in patients with reduced kidney function, patients experiencing severe infections or dehydration, or women who are pregnant or breastfeeding. Additionally, it should be temporarily discontinued during certain periods before and after surgery, and caution is necessary for patients with poor nutritional status or impaired liver function. During treatment, hypoglycemic symptoms may occur, so patients, especially those taking other hypoglycemic agents, should carefully monitor their blood sugar levels. Symptoms of hypoglycemia include dizziness, cold sweats, and tremors. Patients taking this medication should undergo regular kidney function and blood tests, and it is advisable to check vitamin B12 levels as well. Alcohol consumption should be avoided as it can increase the risk of lactic acidosis. Due to potential drug interactions, patients taking other medications should consult their doctor or pharmacist, particularly when using medications that may affect kidney function. Elderly patients or those with compromised kidney function may require dosage adjustments, and this medication is not recommended for children or pregnant women. In cases of overdose, patients should seek medical attention immediately for appropriate treatment, which may include blood dialysis if necessary. If any unusual symptoms or discomfort occur while taking this medication, patients must inform their healthcare provider.

Serious side effects

Urticaria, angioedema, anaphylaxis, Steven-Johnson syndrome and other exfoliative skin diseases, hemorrhagic or necrotizing pancreatitis, acute pancreatitis, acute renal failure, severe and disabling arthralgia, bullous pemphigoid, severe hypoglycemia, acute renal failure, lactic acidosis, acute pancreatitis, hepatic abnormalities (liver dysfunction), severe neurological symptoms (confusion), severe edema, and edema associated with high blood pressure

Mild side effects

• Diarrhea
• upper respiratory infections
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• joint pain
• muscle pain

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, avoid storing it in extremely hot or cold locations, and it is recommended to keep it at room temperature between 1 degree and 30 degrees Celsius.

Appearance

Bright green, oval-shaped, biconvex extended-release film-coated tablet

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle