Janux XR Controlled-release Tablets 50/750 mg (Sitagliptin, Metformin)

Adult dose

For this medication 100/1000 mg controlled-release tablets, take 1 tablet once daily. For this medication 50/500 mg controlled-release tablets, 50/750 mg controlled-release tablets, or 50/1000 mg controlled-release tablets, take 2 tablets together once daily. 1. For patients not currently treated with metformin: The initial dose is a total daily amount of 100 mg sitagliptin and 1000 mg metformin.

This medication contains sitagliptin and metformin, both of which are diabetes treatments that assist in blood sugar control. Firstly, sitagliptin can rarely cause severe allergic reactions; therefore, if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck appear, you must immediately stop taking this medication and consult a doctor. Furthermore, acute pancreatitis can occur, so if there are symptoms such as abdominal pain, nausea, or vomiting, you should promptly inform your healthcare provider. Metformin can rarely cause lactic acidosis, a serious metabolic disorder that results from excessive accumulation of lactate in the body. Symptoms such as fatigue, muscle pain, difficulty breathing, or abdominal pain warrant an immediate visit to the hospital. Particularly, it is safest not to take this medication if you have poor kidney function, decreased liver function, severe infections, or are in a state of dehydration. This medication should not be administered to patients with moderate to severe renal impairment, acute heart failure or myocardial infarction, patients with severe infections, or women who are pregnant or breastfeeding. During treatment, regular monitoring of kidney function and blood tests should be conducted, and periodically checking Vitamin B12 levels is advisable. In addition, excessive alcohol consumption should be avoided while taking this medication, and caution is needed for intense exercise or irregular meal intake, which may increase the risk of hypoglycemia or lactic acidosis. If you are to undergo surgery or procedures using iodine contrast agents, you must temporarily discontinue this medication, and resume it only after confirming that kidney function is normal. Finally, there may be interactions when this medication is taken with other blood glucose-lowering agents, certain diuretics, or antihypertensive drugs, so be sure to inform your healthcare provider about any other medications you are taking.

Serious side effects

Hives, anaphylaxis, angioedema, exfoliative skin conditions including Stevens-Johnson syndrome, fatal/non-fatal hemorrhagic or necrotizing pancreatitis, acute pancreatitis, acute renal failure, acute worsening of renal function, lactic acidosis, hypoglycemia, thrombocytopenia, bullous pemphigoid, increased liver enzyme levels, liver abnormalities (jaundice), severe and disabling joint pain, worsening of renal function

Mild side effects

Diarrhea, upper respiratory tract infection, headache, nausea, vomiting, abdominal pain, nasopharyngitis, constipation, muscle pain, limb pain, back pain, pruritus, thrombocytopenia, rhabdomyolysis, joint pain associated with severe and disabling symptoms

This medication should be stored in a tightly closed container to prevent exposure to air and moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius to ensure the medication's effectiveness over time.

Appearance

Bright green, oval-shaped, biconvex controlled-release film-coated tablets

Package unit

28 tablets/bottle, 30 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle