Dapagliflozin Metformin Sustained-release Tablet 10/500 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dose is once daily dapagliflozin 10 mg/sustained-release metformin 2000 mg, administered as 2 tablets of 5 mg/1000 mg. For initial therapy, the recommended starting dose is one tablet of 5 mg/500 mg or 10 mg/500 mg once daily. To reduce gastrointestinal side effects of metformin, the dose should be adjusted gradually.

This medication contains metformin and dapagliflozin, which are diabetes treatments. Though rare, a serious condition called lactic acidosis can occur while taking this medication, so it should not be used in cases of impaired kidney function or severe infections, or dehydration. Furthermore, caution is necessary when used in conjunction with insulin or sulfonylureas, as hypoglycemia may occur. Patients with moderate or severe impaired kidney function, heart failure, acute myocardial infarction, sepsis, or acute diseases with cardiovascular collapse should also avoid this medication. Patients scheduled for tests using iodine contrast agents should stop taking this medication 48 hours prior to the test and begin again only after ensuring normal kidney function post-test. Pregnant or breastfeeding women should not use this medication, and patients with genetic issues such as lactose intolerance should also refrain from using it. Elderly patients or those with decreased kidney function should have their kidney function closely evaluated before taking this medication, and kidney function, blood pressure, and fluid status should be monitored regularly during treatment. This medication may cause reduced fluid volume or low blood pressure due to increased urination, so caution is advised for patients with symptoms of dehydration or low blood pressure. Genital infections or urinary infections may occur during treatment; if related symptoms arise, consult a doctor immediately. The metformin component can cause vitamin B12 deficiency, so blood serum vitamin B12 levels should be checked during prolonged use. Excessive alcohol consumption may elevate the risk of side effects from this medication, so avoiding alcohol during treatment is recommended. This medication may interact with other drugs, so dosage adjustments and monitoring are necessary according to medical advice, especially when used with diuretics, antihypertensives, insulin, etc. In case of overdose, immediate medical attention should be sought, and patients with impaired kidney function may require dialysis treatment. Finally, the safety of this medication has not been established in children, and caution is needed as dizziness may occur when driving or operating machinery.

Serious side effects

Lactic acidosis, severe hypoglycemia, severe edema or urination abnormalities, severe skin reactions (severe rash with fever, blisters, skin peeling, oral/eye mucous membrane pain), severe allergic reactions (hives, severe swelling, chest tightness, breathing difficulties, cold sweat, pallor), respiratory problems (difficulty breathing or shortness of breath, asthma attacks, cough accompanied by fever along with respiratory abnormalities), liver abnormalities (yellowing of the skin or eyes, etc.)

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infection, fungal infection, hypoglycemia (when used with sulfonylureas or insulin), dry mouth, dizziness, constipation, low back pain, dysuria, polyuria, nocturia, pruritus of the vulva, pruritus of the genital area, elevated hematocrit, initial decreased renal creatinine clearance, dyslipidemia, elevated serum creatinine at the start of treatment, elevated blood urea, weight loss

This medication may be sensitive to air or humidity, so it should be stored in a tightly closed container. The recommended storage temperature is room temperature between 1 to 30 degrees Celsius. This will help maintain the effectiveness and safety of the medication for a long time.

Appearance

Pink, double-sided convex oval film-coated tablet

Package unit

30 tablets/bottle