Dapagliflozin Metformin Extended-Release Tablet 5/1000 mg

Adult dose

The dosage of this medication should be individualized based on the patient's current treatment regimen, efficacy, and tolerability, without exceeding the maximum recommended doses of dapagliflozin 10 mg and extended-release metformin 2000 mg. Generally administered once daily with the evening meal. The maximum dose is 10 mg of dapagliflozin/2000 mg of extended-release metformin once daily, which is taken as 2 tablets of 5 mg/1000 mg. In cases of prior diabetes medication treatment,

This medication is used to help manage diabetes and control blood sugar levels. However, it should not be administered to patients with poor kidney function, severe infections, or dehydration. Caution is needed particularly in patients with moderate to severe kidney impairment, as taking this medication may pose a risk. Rarely, it can cause serious metabolic complications called lactic acidosis, which can be life-threatening; immediate medical attention should be sought if symptoms occur. Additionally, when taken with insulin or sulfonylureas, there is a risk of hypoglycemia, so blood glucose levels should be carefully monitored. During the course of treatment, urinary and genital infections may occur, so prompt treatment is necessary if infection symptoms arise. Pregnant or breastfeeding women should not take this medication and must discontinue it immediately if pregnancy is confirmed. Elderly patients or those with impaired kidney function should have their renal function regularly monitored before and during treatment, and dosage adjustment may be necessary. This medication should be temporarily discontinued before and after surgery or tests using iodinated contrast agents and restarted only after confirming normal kidney function. It may cause dehydration, hypotension, or reduced fluid volume, so special monitoring is required for elderly patients or those on diuretics. There are no specific antidotes for overdose, so appropriate treatment should be administered based on symptoms, and the metformin component can be removed via dialysis. It is advisable to avoid alcohol consumption during treatment, and regular monitoring may be necessary as vitamin B12 levels can decrease. Caution is advised as dizziness may occur when driving or operating machinery, and it should be kept out of reach of children.

Serious side effects

Lactic acidosis, severe hypoglycemia, severe kidney injury, acute kidney injury and dysfunction, severe edema or hypotension, diabetic ketoacidosis, urosepsis and pyelonephritis, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), severe skin reactions (severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes), respiratory issues (shortness of breath or difficulty breathing)

Mild side effects

Vulvovaginitis, glans inflammation and related genital infections, urinary tract infection, fungal infection, hypoglycemia, thirst, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, increased hematocrit, initial increase in serum creatinine, elevated blood urea, dyslipidemia, weight loss, headaches, sensory disturbances, tremors, upper abdominal pain, dyspepsia, abdominal discomfort, diarrhea, abdominal pain, irritable bowel syndrome

This medication must be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature to preserve the medicinal effect for a longer duration.

Appearance

Pink or dark pink biconvex oval film-coated tablets

Package unit

30 tablets/bottle