Dapagliflozin Met Extended-Release Tablet 5/500 mg

Adult dose

This medication is typically administered once daily with the evening meal. The maximum dosage is 10 mg of dapagliflozin and 2000 mg of extended-release metformin, taken as 2 tablets of 5 mg/1000 mg. For initial therapy, the recommended starting dose is one tablet of 5 mg/500 mg or 10 mg/500 mg once daily. Gradual dosage adjustments are made to reduce gastrointestinal side effects from metformin.

This medication is used for diabetes treatment and contains metformin and dapagliflozin. This medication should not be used in patients with poor kidney function or certain heart diseases and liver dysfunction. Before administration, kidney function and fluid status must be confirmed, and caution is especially needed in elderly patients or those with dehydration. Hypoglycemic symptoms may occur during treatment; therefore, dosage adjustments may be necessary when taken with insulin or other blood glucose-lowering agents. Lactic acidosis, a rare side effect, can be life-threatening, so if symptoms such as fatigue, muscle pain, or shortness of breath occur, immediate consultation with medical personnel is required. The risk of genital and urinary tract infections may increase, so prompt treatment should be sought if infection symptoms arise. Pregnant or breastfeeding women should not use this medication; if planning to become pregnant, consult a physician. The risk of side effects may increase when taking this medication with alcohol, so excessive drinking should be avoided. In cases of overdose, immediate medical attention is necessary; dialysis may be required. The safety and efficacy of this medication in children have not been established, so it should not be used in children. Regular monitoring of kidney function and serum vitamin B12 levels is recommended during treatment. Caution is required when driving or operating machinery as dizziness may occur.

Serious side effects

Lactic acidosis, severe hypoglycemia, severe allergic reactions, acute kidney injury, urinary tract sepsis, pyelonephritis, severe edema, severe skin adverse reactions (severe rashes, blisters, skin peeling, mucosal pain in mouth/eyes), liver abnormalities (jaundice), sudden and very severe headaches, seizures, altered consciousness, vision disturbances, paralysis, severe respiratory issues (shortness of breath, asthma attacks, respiratory abnormalities accompanied by coughing and fever), Guillain-Barré syndrome.

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia (when used with sulfonylurea or insulin), dry mouth, dizziness, constipation, back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, dyslipidemia, increased serum creatinine, increased serum urea, weight loss, headache, paresthesia, tremor, abdominal discomfort, dyspepsia, diarrhea,

This medication may be sensitive to air and moisture, so it must be stored in a tightly sealed container. It is recommended to maintain storage temperature between 1 degree and 30 degrees Celsius to safely preserve the effectiveness of the medication.

Appearance

Orange, biconvex, oval film-coated tablet.

Package unit

30 tablets/bottle