Dapaone M Extended-Release Tablet 10/1000 milligrams

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dosage is 10mg of dapagliflozin/2000mg of extended-release metformin taken as 2 tablets of 5mg/1000mg once daily. The recommended starting dose for initial therapy is 1 tablet of either 5mg/500mg or 10mg/500mg taken once daily. The dosage should be titrated gradually to minimize gastrointestinal side effects of metformin.

This medication can very rarely cause a serious condition known as lactic acidosis, so attention should be paid to these symptoms. Care should be taken as hypoglycemia may occur when used with other diabetes medications. Patients with severely impaired kidney function or conditions affecting the kidneys such as dehydration or severe infections should not use this medication. Pregnant or nursing women should also refrain from taking this medication. Elderly patients or those with slightly impaired kidney function should regularly monitor kidney function and fluid status while using this medication. This medication may increase the risk of genital and urinary tract infections, so if signs of infection occur, consult healthcare professionals immediately. Prolonged use may lead to vitamin B12 deficiency, so it is advisable to check blood levels if taking for an extended period. If planning for surgery or radiological imaging with contrast agents, discontinue this medication in advance and restart after confirming normal kidney function. Alcohol may increase the risk of side effects associated with this medication; therefore, excessive drinking should be avoided during use. Dizziness or hypotension may occur while taking this medication, so caution is needed when driving or operating machinery. If any unusual symptoms occur while taking this medication, consult a doctor immediately for appropriate measures.

Serious side effects

• Severe lactic acidosis
• severe hypoglycemia
• acute deterioration of kidney function
• cardiopulmonary disease
• septicemia
• ketosis
• lactic acidosis
• severe allergic reactions
• urinary sepsis
• pyelonephritis

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, hypoglycemia, thirst, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, increased hematocrit, reduced renal creatinine clearance at the start of treatment, dyslipidemia, increased serum creatinine at the start of treatment, elevated blood urea, weight loss, diarrhea, nausea/vomiting, vitamin B12 reduction/deficiency, abdominal pain

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It is important to maintain a storage temperature between 1 and 30 degrees Celsius to preserve the efficacy of the medication.

Appearance

Yellow or dark yellow bilaterally convex oval film-coated tablets

Package unit

30 tablets/bottle