Poshvet Duo Extended Release Tablet 10/500 mg

Adult dose

This drug is usually administered once a day with the evening meal. The maximum dosage is once daily 10 mg of dapagliflozin/2000 mg of extended-release metformin, given as 2 tablets of 5 mg/1000 mg. If there is no previous experience with diabetes medication treatment, the initial therapy should be 1 tablet of 5 mg/500 mg or 10 mg/500 mg taken once daily. This drug should be swallowed whole and must not be crushed, cut, or chewed.

This drug is used for the treatment of diabetes and should not be administered to patients with impaired kidney function or severe kidney disease. It may very rarely cause a serious metabolic complication known as lactic acidosis, which can be life-threatening, so caution is needed. When used together with insulin or sulfonylurea medications, the risk of hypoglycemia may increase, and dosage adjustments may be necessary in such cases. Patients with reduced fluid volume or at risk of hypotension should be monitored for blood pressure and kidney function while using this drug. This drug may increase the risk of genital and urinary tract infections, so if infection symptoms appear, immediate medical consultation and treatment are required. Pregnant or breastfeeding women should not use this drug, and women who may become pregnant should immediately discontinue use upon confirmation of pregnancy. Older adults may have an increased risk of decreased kidney function, and careful dosage adjustments and regular kidney function tests are necessary. The risk of lactic acidosis may increase when taken with alcohol, so excessive drinking should be avoided while on this medication. Before and after surgery or examinations using iodine contrast agents, this medication should be temporarily discontinued, and kidney function should be checked before re-administration. In overdose situations, appropriate symptomatic treatment is needed, and the metformin component can be removed by dialysis, which may be helpful in emergencies. While taking this medication, if symptoms of hypoglycemia or lactic acidosis such as fatigue, muscle pain, or difficulty breathing occur, inform the doctor immediately, and regular blood tests and kidney function checks are recommended.

Serious side effects

• Severe lactic acidosis, severe hypoglycemia, lactic acidosis, acute kidney dysfunction, cardiopulmonary disease, sepsis, abnormalities in red blood cells associated with lactic acidosis,
• serious allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor),
• severe skin reactions (severe rashes with fever, blisters, skin peeling, pain in oral/ocular mucosa),
• respiratory problems (shortness of breath or difficulty breathing, asthma attacks, cough + sputum.

Mild side effects

Vulvitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia (when used with sulfonylureas or insulin), reduced fluid volume, dry mouth, dizziness, constipation, dry mouth, low back pain, painful urination, polyuria, nocturia, vulvar pruritus, genital pruritus, increased hematocrit, decreased renal creatinine clearance at the beginning of treatment, dyslipidemia, increased serum creatinine at the beginning of treatment, increased blood urea nitrogen.

This drug should be stored in a tightly sealed container to prevent exposure to air or moisture. It is also recommended to store it at room temperature between 1°C and 30°C away from direct sunlight.

Appearance

Pink, oval, biconvex film-coated tablet

Package unit

30 tablets/bottle