Dapagliflozin Metformin Extended-Release Tablets 10/500 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dosage is 10 mg of dapagliflozin/2000 mg of extended-release metformin taken once daily, administered as two tablets of 5 mg/1000 mg. For patients who have no previous experience with diabetes medications and have difficulty achieving adequate blood sugar control with monotherapy, the initial regimen involves taking one tablet of 5 mg/500 mg or 10 mg/500 mg once daily. This

This medication is used for the treatment of diabetes and helps in controlling blood sugar levels. However, it may rarely cause a serious side effect called lactic acidosis, so caution is needed. When used in combination with other diabetes medications, there may be an increased risk of hypoglycemia, requiring dosage adjustments. Patients with impaired kidney function, dehydration, severe infections, or weak heart function should not use this medication. It should also be discontinued for a certain period before and after surgeries or diagnostic tests involving radiopaque agents, and it should be resumed only after confirming normal kidney function. Pregnant or lactating women should not use this medication, and careful use is advised in children and elderly patients. While taking this medication, regular checks of blood sugar and kidney function are necessary, and patients should be vigilant for symptoms of hypoglycemia or dehydration. Additionally, genital or urinary infections may occur, so medical consultation is required immediately if such symptoms arise. This medication may lower vitamin B12 levels, so it is advisable to check vitamin B12 status during long-term use. Excessive alcohol should be avoided, and there is potential for drug interactions with other medications, so consultation with healthcare professionals is essential regarding co-medication. While taking this medication, fluid volume status and blood pressure should be periodically monitored, and caution should be exercised if dizziness or hypotensive symptoms occur. In case of overdose, immediate medical attention should be sought, and this medication should be kept out of reach of children.

Serious side effects

Lactic acidosis, severe hypoglycemia, severe allergic reactions, acute kidney injury, renal dysfunction, heart failure, diabetic ketoacidosis, urosepsis, pyelonephritis, perineal necrosis, Guillain-Barré syndrome, bacterial pneumonia, sialadenitis, acute cholecystitis, atrial fibrillation, severe skin adverse reactions (severe rash with fever, blisters, skin peeling, pain in mucosal membranes of mouth/eyes), respiratory problems (shortness of breath or difficulty breathing, asthma attacks, cough and fever).

Mild side effects

• Vulvovaginitis
• balanitis and related genital infections
• urinary tract infections
• fungal infections
• hypoglycemia
• dry mouth
• dizziness
• constipation
• back pain
• dysuria

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, avoid extremely hot or cold places, and store it at room temperature between 1 to 30 degrees Celsius.

Appearance

Pink, biconvex, oval-shaped film-coated tablet

Package unit

30 tablets/bottle