Daparon Duo Sustained Release Tablet 10/500 mg

Adult dose

This medication is generally taken once a day with the evening meal. The maximum dosage is one daily dose of 10 mg of dapagliflozin and sustained release 2000 mg of metformin, or two tablets of 5 mg/1000 mg. When initiating therapy in patients without prior experience of diabetes medication, the recommended starting dose is one tablet of either 5 mg/500 mg or 10 mg/500 mg once daily. This medication should be swallowed whole and should not be crushed, split, or chewed.

This medication is used for the treatment of diabetes and helps regulate blood glucose levels. However, it can exceptionally cause a dangerous condition called lactic acidosis, so patients with poor kidney function, severe infections, or heart disease should not use it. Caution is also needed when using it in combination with insulin or sulfonylurea as there is a risk of hypoglycemia. This medication should not be administered to patients with moderate to severe renal impairment, and temporary cessation is required in acute conditions such as dehydration, severe infections, or before and after surgery. Pregnant or breastfeeding women should not use this medication. Regular checks of kidney function, blood pressure, and fluid status should be conducted during use, particularly for the elderly or those on diuretics. This medication may cause side effects such as genital infections, urinary tract infections, hypoglycemia, dehydration, dizziness, constipation, dry mouth, low back pain, urinary pain, polyuria, nocturia, external genital itching, genital itching, increased hematocrit, decreased initial renal creatinine clearance, dyslipidemia, increased serum creatinine at the beginning of treatment, elevated blood urea, weight loss, diarrhea, nausea/vomiting, and vitamin B12 deficiency, so it is advisable to consult medical personnel if symptoms occur. Alcohol consumption can increase the risk of side effects from this medication, so excessive drinking should be avoided during treatment. This medication does not significantly affect driving or machine operation but caution is advisable due to the possibility of dizziness. Finally, store it out of reach of children and keep it in its original container to prevent misuse or degradation of quality.

Serious side effects

Lactic acidosis (severe metabolic complication), severe hypoglycemia, ketoacidosis, urosepsis and pyelonephritis, acute kidney injury and renal dysfunction, Guillain-Barré syndrome, bacterial pneumonia, sialadenitis, chest pain, acute cholecystitis, atrial fibrillation, palpitations, perineal necrosis, urticaria, severe swelling (edema), chest tightness, dyspnea, cold sweat, pallor, high fever with severe rash, blisters, skin peeling, mucosal pain in the mouth/eyes, difficulty breathing.

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, decreased fluid volume, thirst, dizziness, constipation, dry mouth, low back pain, urinary pain, polyuria, nocturia, external genital itching, genital itching, increased hematocrit, decreased initial kidney creatinine clearance, dyslipidemia, increased serum creatinine at the beginning of treatment, elevated blood urea, weight loss, diarrhea, nausea/vomiting, vitamin B12 deficiency.

This medication should be kept in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius at room temperature.

Appearance

Pink, biconvex, rectangular, sustained-release film-coated tablet

Package unit

30 tablets/bottle