Polvitt Capsule 2mg (Pomalokcib)

Adult dose

Before administering this medicine, consider the potential risks and benefits of this medicine and other alternative treatments. Cardiovascular risk increases with higher doses and longer exposure to this medicine; therefore, administer it for the shortest possible duration. Efficacy beyond 6 weeks and the safety of long-term administration beyond 6 months have not been established. Adverse reactions such as hypertension, angina, and edema may occur during treatment with this medicine. Therefore, during treatment, the need to continue therapy based on symptom relief and the response to treatment should be reassessed regularly at least once a month. The recommended dose is 2mg once daily, taken after a meal. Do not exceed a daily dose of 2mg. If there is no therapeutic benefit at the recommended dose, discontinue this medicine and consider an appropriate alternative treatment. Do not administer this medicine because there is no experience with its use.

This medication should be discussed with a physician or pharmacist before use in individuals who regularly consume more than three alcoholic beverages daily. Taking it with alcohol may increase the risk of gastrointestinal bleeding. This medication may affect the cardiovascular system and increase the risk of heart attack, stroke, and similar conditions. Especially if there’s a history of cardiovascular disease or risk factors, it is crucial to take the lowest effective dose for the shortest period. Symptoms such as chest pain, shortness of breath, or speech disturbances should be immediately reported to healthcare professionals. This medication may cause gastrointestinal issues, increasing the risk of bleeding, ulcers, or perforations in the stomach or intestines. These symptoms can occur without any special warnings during use, thus if symptoms like epigastric pain, indigestion, black stool, or vomiting blood occur, one should visit a hospital immediately. Elderly patients or those with a history of gastrointestinal diseases should be particularly cautious. This medication should not be administered to individuals with certain allergic reactions, asthma, hypertension, liver impairment, kidney impairment, heart failure, pregnant women, or nursing mothers. Additionally, it is contraindicated in patients with gastrointestinal bleeding or inflammatory bowel disease. Particular caution is required for patients with asthma, heart failure, hypertension, edema, dehydration, the elderly, or diabetes while using this medication, and it should be taken under a doctor’s guidance. Common side effects during use may include upper abdominal pain, indigestion, headache, elevated blood pressure, cough, and edema, while rare reports include skin rashes, liver function abnormalities, and heart issues. If such unusual symptoms occur, immediate notification to healthcare personnel is necessary. This medication is metabolized in the liver, so there may be interactions with other drugs when taken together. Consult with a doctor, particularly when using medications that inhibit liver metabolic enzymes, anticoagulants, diuretics, ACE inhibitors, lithium, or methotrexate; blood pressure and kidney function should also be regularly checked. Women who are pregnant or may become pregnant should avoid taking this medication, and nursing mothers should either avoid it or stop breastfeeding. Safety and efficacy in pediatric patients under 18 years have not been established; thus, it is not to be used in this demographic. The elderly may have diminished liver and kidney functions, so careful monitoring is required during use. Regular blood tests and liver and kidney function checks should be conducted during treatment; if abnormalities are identified, discontinuation and consultation with healthcare providers are necessary. In case of overdose, symptoms may include lethargy, drowsiness, nausea, vomiting, and upper abdominal pain, requiring immediate medical treatment.

Gastrointestinal bleeding, serious cardiovascular thromboembolic reactions, myocardial infarction, stroke, upper abdominal pain, dyspepsia, nasopharyngitis, pneumonia, leukoplakia, bronchitis, soft tissue infection, abscess, shingles, influenza, syphilis, urinary tract infection, onychomycosis, colorectal adenoma, anemia, skin papilloma, eosinophilia, hypersensitivity reaction, chemical allergy, diabetes, hypercholesterolemia, hyperkalemia, depressed mood, major depression, headache, insomnia, paresthesia, conscious depressive state, dizziness, drowsiness, lethargy, Alzheimer's type dementia, tremor, eyelid edema, eyelid swelling, blepharitis, eyelid spasm, dryness of the eyes, keratitis, macular hole, ear discomfort, positional vertigo, palpitations, angina, quadrant block, myocardial ischemia, hypertension, arrhythmia, high blood pressure, facial flushing, abnormal blood pressure, cough, dyspnea, asthma, rhinorrhea, oropharyngalgia, productive cough, rhinitis, allergic rhinitis, upper abdominal pain, diarrhea, nausea, abdominal pain, vomiting, bowel motility disorder, irritable bowel syndrome, change in stool color, food poisoning, gastric ulcer, gingivitis, dental disorders, dry mouth, enteritis, upper abdominal discomfort, gastritis, abdominal discomfort, lower abdominal pain, aphthous stomatitis, constipation, gastroesophageal reflux disease, colonic polyps, esophagitis, hyperbilirubinemia, facial swelling, urticaria, erythema, neurodermatitis, itching, generalized itching, dry eczema, arthralgia, back pain, flat feet, joint swelling, neck pain, limb pain, plantar fasciitis, musculoskeletal pain, intervertebral disc herniation, muscle cramps, frequent urination, chronic kidney failure, microalbuminuria, urinary stones, breast pain, chest discomfort, facial edema, edema, peripheral edema, fatigue, generalized edema, influenza-like illness, weight gain, asthenia, thirst, contusion, abrasion, laceration, traffic accident, spinal compression fracture, chills, fever, insect bites, concussion, ligament rupture, ligament sprain, wound, wrist fracture, warmth, drug overdose, neutrophilia, reduced unsaturated iron binding capacity, prolonged prothrombin time, decreased hemoglobin, increased alanine aminotransferase, increased aspartate aminotransferase, increased creatine phosphokinase, increased serum creatinine, stroke, sensory disturbances, sensory loss, rash, drug rash, skin erosion, tachycardia, conjunctival hyperemia, gastrointestinal disturbances, abdominal distension, decreased appetite, daydreaming, dysuria, lethargy, drowsiness, nausea, vomiting, upper abdominal pain, hypertension, acute kidney failure, respiratory depression, coma

This medication may be sensitive to air and moisture, thus it should be stored in a sealed container. It is recommended to keep the storage temperature between 1 to 30 degrees Celsius at room temperature. This way, the medication’s effectiveness can be preserved for a longer duration.

Appearance

A hard capsule with a white to light yellow powder inside, white in color.

Package unit

30 capsules per bottle, 100 capsules per bottle