Plex Capsule 2 mg (Pomalidomide)

Adult dose

Before administering this medicine, consider the potential risks and benefits of this medicine and other alternative treatments. Cardiovascular risk increases with higher doses and longer exposure to this medicine; therefore, administer it for the shortest possible duration. Efficacy beyond 6 weeks and the safety of long-term administration beyond 6 months have not been established. Adverse reactions such as hypertension, angina, and edema may occur during treatment with this medicine. Therefore, during treatment, the need to continue therapy based on symptom relief and the response to treatment should be reassessed regularly at least once a month. Adults: The recommended dose is 2mg once daily, taken after a meal. Do not exceed a daily dose of 2mg. If there is no therapeutic benefit at the recommended dose, discontinue this medicine and consider an appropriate alternative treatment. Patients with hepatic or renal impairment: Do not administer this medicine because there is no experience with its use.

Patients who regularly consume more than 3 drinks a day should consult a doctor or pharmacist before taking this medication due to the risk of gastrointestinal bleeding. This medication may affect the cardiovascular system, increasing the risk of myocardial infarction and stroke; thus, it should be used at the minimum effective dose for the shortest duration, and any cardiovascular symptoms should be reported to healthcare professionals immediately. Serious gastrointestinal issues such as gastrointestinal bleeding, ulcers, and perforations may occur, especially in individuals with a history of gastrointestinal disorders. If symptoms appear, immediate treatment is necessary. This medication should not be used in patients with specific allergies, or those with impaired heart, kidney, or liver function, pregnant or breastfeeding women, and patients with certain cardiovascular diseases. Increased caution and monitoring may be necessary for patients with asthma, hypertension, edema, elderly patients, and those with diabetes. Various side effects such as headaches, dyspepsia, increased blood pressure, edema, and skin rashes may occur during use. If any abnormal symptoms arise, consulting with healthcare personnel is advised. This medication may affect liver and kidney function, necessitating regular blood tests and liver/kidney function assessments; treatment should be discontinued if abnormalities are found. Interactions with other medications may occur, particularly those affecting liver metabolism, diuretics, anticoagulants, lithium, and methotrexate, so consult a doctor before co-administration. Women who are pregnant or planning to become pregnant should avoid this medication as it may affect the fetus, and breastfeeding women should either discontinue the medication or stop breastfeeding. Its safety and efficacy have not been established in children and adolescents under 18 years of age; therefore, it is advisable not to use in this population. Elderly patients are at greater risk of declining kidney, liver, and heart function, and should be monitored closely during treatment. In cases of overdose, symptoms such as lethargy, drowsiness, nausea, vomiting, and abdominal pain may appear, requiring immediate medical attention. This medication should be stored out of reach of children, and transferring it to another container may impair its quality.

Gastrointestinal bleeding, severe cardiovascular thrombotic events, myocardial infarction, cerebrovascular accident, upper abdominal pain, dyspepsia, nasopharyngitis, pneumonia, tinea capitis, bronchitis, soft tissue infection, boils, herpes zoster, influenza, syphilis, urinary tract infection, onychomycosis, colorectal adenoma, anemia, skin papilloma, eosinophilia, hypersensitivity reactions, chemical allergy, diabetes, hypercholesterolemia, hyperkalemia, depressed mood, major depressive disorder, headache, insomnia, sensory disturbances, conscious depressive state, dizziness, drowsiness, lethargy, Alzheimer-type dementia, tremors, ocular edema, eyelid edema, blepharitis, eyelid spasm, dry eyes, keratitis, macular hole, ear discomfort, positional vertigo, palpitations, angina, angle blockage, myocardial ischemia, elevated blood pressure, arrhythmia, hypertension, facial flushing, abnormal blood pressure, cough, dyspnea, asthma, runny nose, oropharyngeal pain, wet cough, rhinitis, allergic rhinitis, upper abdominal pain, diarrhea, nausea, abdominal pain, vomiting, bowel motility disorder, irritable bowel syndrome, stool discoloration, food poisoning, gastric ulcer, gingivitis, dental disorders, dry mouth, enteritis, upper abdominal discomfort, gastritis, abdominal discomfort, lower abdominal pain, aphthous stomatitis, constipation, gastroesophageal reflux disease, colorectal polyps, esophagitis, hyperbilirubinemia, facial swelling, urticaria, erythema, neurodermatitis, itching, generalized itching, dry eczema, arthralgia, back pain, flat feet, joint swelling, neck pain, limb pain, plantar fasciitis, musculoskeletal pain, intervertebral disc herniation, muscle cramps, polyuria, chronic renal failure, microalbuminuria, urinary stones, breast pain, chest discomfort, facial edema, edema, peripheral edema, fatigue, generalized edema, influenza-like illness, weight gain, asthenia, thirst, contusion, abrasion, laceration, traffic accident, spinal compression fracture, chills, fever, insect bite, concussion, ligament rupture, ligament sprain, wound, wrist fracture, warmth sensation, drug overdose, neutrophilia, decreased unsaturated iron binding capacity, prolonged prothrombin time, decreased hemoglobin, increased alanine aminotransferase, increased aspartate aminotransferase, increased creatine phosphokinase, elevated serum creatinine, stroke, perceptual disturbances, sensory reduction, rash, drug rash, skin erosion, tachycardia, conjunctival injection, gastrointestinal disorders, abdominal distension, decreased appetite, daydreaming, urinary difficulty, lethargy, drowsiness, nausea, vomiting, upper abdominal pain, hypertension, acute renal failure, respiratory depression, coma, exfoliative dermatitis, mucocutaneous syndrome, toxic epidermal necrolysis, skin rash, mucosal lesions, blisters, fever, itching, severe bronchospasm

This medication should be stored in a tightly sealed container to prevent air and moisture ingress. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

A solid white capsule containing a white to light yellow powder

Package unit

30 capsules/bottle, 100 capsules/bottle