Janumax MXR Sustained-Release Tablet 100/1000 mg

Adult dose

The 100/1000 mg sustained-release tablet should be taken once daily, with one tablet per dose. Patients taking the 50/500 mg sustained-release tablet or the 50/1000 mg sustained-release tablet should take two tablets at once once daily. 1. For patients not currently treated with metformin: The initial total daily dose of this medication is 100 mg of sitagliptin and 1000 mg of metformin. If necessary, the dose of metformin can be increased gradually.

This medication consists of two components: sitagliptin and metformin. First, the sitagliptin component can rarely cause severe allergic reactions, so if symptoms such as rash, difficulty breathing, or swelling of the face or neck occur, stop taking the medication and consult a doctor immediately. There is also a risk of acute pancreatitis, which is inflammation of the pancreas, so if symptoms such as abdominal pain, nausea, or vomiting occur, inform healthcare personnel immediately. The metformin component can cause lactic acidosis, a rare but fatal metabolic complication. Caution is particularly necessary for patients with diminished kidney function, liver dysfunction, dehydration, severe infections, or heart disease. This medication is not to be administered to patients with moderate to severe renal impairment, acute heart failure or myocardial infarction, pregnant or lactating women, and individuals with type 1 diabetes. Regular monitoring of kidney function and blood tests should be conducted while on treatment, and vitamin B12 levels may decrease, so periodic testing is recommended. Additionally, excessive alcohol consumption should be avoided during treatment, and treatment should be temporarily discontinued prior to surgery or imaging tests with contrast agents. As there is a risk of hypoglycemia, caution is advised when skipping meals or performing intensive exercise, and the possibility of hypoglycemia may increase if taken with other hypoglycemic agents. Finally, if any unusual symptoms such as sudden joint pain or skin blisters occur while taking this medication, inform a doctor immediately.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, Stevens-Johnson syndrome, rash, cutaneous vasculitis, exfoliative skin disease, fatal/non-fatal hemorrhagic or necrotizing pancreatitis, acute pancreatitis, acute renal failure, deterioration of renal function, jaundice (liver dysfunction), severe hypoglycemia, lactic acidosis, severe lactic acidosis, bullous pemphigoid, elevated liver enzymes, rhabdomyolysis, acute pancreatitis, acute renal failure, severe and debilitating swelling accompanied by arthralgia

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• myalgia
• limb pain

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The storage temperature should be maintained at room temperature between 1 degree and 30 degrees Celsius. This will help preserve the effectiveness of the medication for a longer period.

Appearance

Bright blue, double-convex oval-shaped sustained-release film-coated tablet

Package unit

Bottle packaging - 28 tablets/bottle, bottle packaging - 56 tablets/bottle, bottle packaging - 200 tablets/bottle