Janumet XR 100/1000 mg Extended-Release Tablets

Adult dose

The 100/1000 mg extended-release tablets should be taken once daily, 1 tablet at a time. Patients taking the 50/500 mg extended-release tablets or the 50/1000 mg extended-release tablets should take 2 tablets at once, once daily. 1. For patients not currently receiving treatment with metformin: The initial dose is a total daily amount of 100 mg of sitagliptin and 1000 mg of metformin. If sufficient blood sugar control is difficult...

This medication contains sitagliptin and metformin for diabetes treatment, so there are several precautions to consider when taking it. First, this medication may cause allergic reactions, so if symptoms such as rash, hives, or difficulty breathing occur, discontinue use immediately and consult a doctor. Additionally, acute pancreatitis, a type of pancreatic inflammation, can rarely occur, so if symptoms such as abdominal pain, nausea, or vomiting develop, inform medical personnel immediately. This medication should not be given to patients with reduced kidney function, and regular tests should be done to ensure normal kidney function. In particular, it may be dangerous to use this medication in patients with moderate to severe kidney impairment, serious infections, dehydration, heart failure, or acute myocardial infarction. It is necessary to halt the use of this medication for a certain period before and after surgery and to restart it only after confirming that kidney function has recovered post-surgery. It is safe to avoid this medication during pregnancy or in breastfeeding women. This medication may induce hypoglycemia, so extra caution is necessary if meals are skipped or irregular, during intense exercise, or when combined with other hypoglycemic agents. Furthermore, alcohol consumption can increase the risk of serious side effects such as lactic acidosis, so it is advisable to avoid drinking while on this medication. During the course of taking this medication, regular monitoring of blood sugar, kidney function, and blood tests is essential, and checking vitamin B12 levels is also necessary. Finally, if any unusual symptoms or discomfort occur during the course of taking this medication, it is vital to consult medical personnel immediately to receive appropriate measures.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, severe skin reactions (Stevens-Johnson syndrome, exfoliative dermatitis, bullous pemphigoid), acute pancreatitis, acute renal failure, liver abnormalities (elevated liver enzymes, risk of jaundice), severe hypoglycemia, severe joint pain associated with disabilities, severe allergic reactions, severe edema, significant neurological symptoms (risk of seizures), acute or chronic lactic acidosis, respiratory problems (breathing difficulties)

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• myalgia
• limb pain

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture, and it is crucial to maintain a storage temperature between 1 to 30 degrees Celsius. By storing it this way, the effectiveness of the medication can be safely preserved for an extended period.

Appearance

Bright blue, oval-shaped, bilaterally convex extended-release film-coated tablet

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle