Janumet XR Extended Release Tablets 50/1000 Milligrams

Adult dose

The dosage of this medication is determined based on the patient's current treatment regimen, efficacy, and tolerability, ensuring it does not exceed the limits of sitagliptin 100 mg and metformin 2000 mg. This medication should be taken with food in the evening once daily to minimize gastrointestinal side effects caused by metformin, with gradual dose escalation. To maintain the extended-release properties, it should be swallowed whole and not split, crushed, or chewed.

This medication is used for the treatment of diabetes and contains two components: sitagliptin and metformin. First, an allergic reaction may occur when taking this medication, so if symptoms such as rash, hives, or difficulty breathing develop, discontinue use immediately and consult a physician. Second, acute pancreatitis, which is inflammation of the pancreas, may occur, so if symptoms such as abdominal pain, vomiting, or nausea appear, inform medical staff immediately. Third, due to the metformin component, rare but serious lactic acidosis may occur; if symptoms such as muscle pain, weakness, difficulty breathing, or abdominal pain arise, seek medical attention immediately. Fourth, this medication should not be taken by patients with decreased kidney function, severe infection, dehydration, congestive heart failure, or acute diseases such as myocardial infarction. Fifth, the use of iodine contrast agents for examinations around the time of this medication should be temporarily suspended, and the medication may be resumed only after confirming normal kidney function. Sixth, pregnant women or women who may become pregnant, as well as nursing mothers, should not take this medication. Seventh, caution is advised due to the increased risk of hypoglycemia or lactic acidosis resulting from irregular meals, intense exercise, or interactions with other medications. Eighth, it is important to regularly monitor kidney function, blood tests, and vitamin B12 levels while taking this medication. Ninth, alcohol may increase the risk of side effects from this medication, so it is advisable to avoid drinking alcohol while on this medication. Finally, the safety of this medication in children has not been established, and elderly patients require dose adjustments and caution based on kidney function.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, rash, exfoliative skin diseases such as Stevens-Johnson syndrome, acute pancreatitis, acute renal failure, elevated liver enzymes, and liver abnormalities (including signs related to jaundice), severe hypoglycemia, lactic acidosis, acute pancreatitis, bullous pemphigoid, thrombocytopenia, rhabdomyolysis, severe joint pain with disability.

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a tightly closed container to prevent air or moisture from entering. It is best to store it at room temperature between 1 and 30 degrees Celsius. This will help maintain the medication's effectiveness and ensure safe usage.

Appearance

Light green, oval-shaped, bi-convex extended-release film-coated tablet

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle