Sitafomin XR Extended-Release Tablet 100/1000 mg

Adult dose

The maximum recommended daily dose for each ingredient should not exceed sitagliptin 100 mg and metformin 2000 mg, and must be determined considering the current treatment regimen, efficacy, and tolerability for each patient. This medication should be taken once daily with meals, preferably in the evening, with a gradual increase in dosage. For the 100/1000 mg extended-release formulation of this medication, take one tablet once daily. For the 50/500 mg extended-release tablets or

This medication is a diabetes treatment that contains sitagliptin and metformin and requires several precautions during use. Firstly, this medication can rarely cause serious allergic reactions. Symptoms such as anaphylaxis, angioedema, and skin exfoliating diseases may occur; if any of these symptoms are suspected, the use should be stopped immediately, and consultation with a healthcare professional is necessary. In addition, there is a risk of acute pancreatitis, so if symptoms such as abdominal pain, nausea, or vomiting occur after starting the medication, careful monitoring is needed, and drug administration should be suspended if necessary. Due to the metformin component, rare but serious metabolic complications called lactic acidosis may occur. Symptoms include malaise, muscle pain, difficulty breathing, and abdominal pain; if any of these symptoms occur, it is essential to inform a healthcare professional immediately. Patients with impaired kidney function, liver dysfunction, acute heart failure, myocardial infarction, or who are dehydrated should not use this medication as it may be hazardous. It is also safe for pregnant women or those who might become pregnant, as well as nursing mothers, to avoid using this medication. This medication may cause hypoglycemia, so individuals should be cautious of symptoms when experiencing irregular meals, excessive exercise, or combining with other hypoglycemic agents. Symptoms of hypoglycemia include dizziness, headache, cold sweat, and trembling, and immediate action is required if any abnormal symptoms occur. Moreover, there may be interactions when taking this medication with other medications, so it is important to inform your healthcare provider about all medications being taken and to regularly monitor blood glucose and kidney function. Before and after surgery, the use of this medication should be temporarily halted, and should be resumed only once oral intake is restored and kidney function has returned to normal. Finally, excessive alcohol consumption should be avoided during the use of this medication, and regular blood tests are recommended as levels of vitamin B12 may decrease. To safely use this medication, it is important to understand these points well, and immediate consultation with healthcare professionals is necessary if any abnormal symptoms appear.

Serious side effects

• Hives
• severe swelling (angioedema)
• chest tightness
• difficulty breathing
• anaphylaxis
• rash
• Stevens-Johnson syndrome
• cutaneous vasculitis
• severe rash with high fever
• blisters

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication must be stored in a tightly sealed container to protect it from exposure to air or moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius to ensure the safety of the drug’s effectiveness.

Appearance

Bright blue, oval-shaped, film-coated extended-release tablet with a convex surface on both sides

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle