Sitagliptin Metformin Extended Release Tablets 100/1000 mg

Adult dose

The dosage of this medication is determined within the limits of a maximum of 100 mg of sitagliptin per day and a maximum of 2000 mg of metformin per day. This medication is taken once daily, either as 1 tablet (100/1000 mg extended release) or as 2 tablets (50/500 mg or 50/1000 mg extended release) once daily. The initial dosage is 100 mg of sitagliptin and 1000 mg of metformin as needed.

This medication is a diabetes treatment containing sitagliptin and metformin. Firstly, an allergic reaction may occur during the use of this medication, so if symptoms such as skin rash, hives, or difficulty breathing arise, you should stop taking the medication immediately and consult a doctor. Additionally, serious side effects such as acute pancreatitis, characterized by inflammation of the pancreas, may develop, so it is important to carefully monitor for symptoms such as abdominal pain, vomiting, and loss of appetite. The metformin contained in this medication can rarely cause lactic acidosis, a dangerous metabolic complication that may present with symptoms such as severe fatigue, muscle pain, difficulty breathing, and abdominal pain. If such symptoms occur, notify medical personnel immediately. Patients with poor kidney function, severe infections, dehydration, heart failure, liver dysfunction, as well as pregnant or breastfeeding women should not take this medication, and it should also be temporarily discontinued around the time of surgery. When taken with other medications that have strong blood sugar-lowering effects, hypoglycemia may occur, so it is important to frequently check blood sugar levels and respond immediately if symptoms of hypoglycemia, such as dizziness, cold sweat, or tremors, are experienced. Regular monitoring of kidney function and blood tests should be performed during the course of this medication, and since vitamin B12 levels may decrease, supplementation may be necessary if needed. Furthermore, alcohol consumption may increase the risk of lactic acidosis, so avoiding drinking is advisable. Finally, this medication has not been established as safe and effective for children under 18 years of age, so it is best to avoid administering it to this age group. It is important to adhere to the aforementioned precautions while taking this medication and to seek immediate medical advice if any unusual symptoms appear.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, tightness in the chest, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain of mucous membranes in mouth/eyes, Stevens-Johnson syndrome including exfoliative dermatitis, severe skin adverse reactions, acute pancreatitis (hemorrhagic or necrotizing pancreatitis, fatal/non-fatal), acute renal failure, worsening of kidney function, shortness of breath or difficulty breathing, asthma attack

Mild side effects

Diarrhea, upper respiratory tract infection, headache, nasopharyngitis, constipation, vomiting, abdominal pain, muscle pain, limb pain, back pain, pruritus, thrombocytopenia, rhabdomyolysis, hypoglycemia, joint pain without severe or disabling symptoms

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, avoid extremely hot or cold environments, and it is safest to store it at room temperature between 1°C and 30°C.

Appearance

Bright blue elliptical extended-release film-coated tablets that are convex on both sides

Package unit

Bottle packaging - 28 tablets/bottle, Bottle packaging - 56 tablets/bottle, Bottle packaging - 200 tablets/bottle