Promet XR Controlled-Release Tablet 50/1000 mg

Adult dose

For the 100/1000 mg controlled-release tablet, take 1 tablet once daily. For patients taking the 50/500 mg controlled-release tablet or the 50/1000 mg controlled-release tablet, take 2 tablets simultaneously once daily. 1. Patients currently not receiving treatment with metformin: The initial dosage is a total daily amount of sitagliptin 100 mg and metformin 1000 mg. Gradually increase the metformin.

This medication contains both sitagliptin and metformin to assist with blood sugar control in patients with type 2 diabetes. First, sitagliptin can rarely cause severe allergic reactions; if symptoms such as skin rash, difficulty breathing, or swelling of the face or throat occur, discontinue use immediately and consult a doctor. Additionally, sitagliptin carries a risk of acute pancreatitis, so if symptoms such as abdominal pain, nausea, vomiting, or loss of appetite occur, monitor closely and inform a physician. The metformin component can rarely induce a serious condition known as lactic acidosis, which is dangerous due to excessive lactic acid buildup in the body. If symptoms such as fatigue, muscle pain, difficulty breathing, or abdominal pain occur, immediate medical attention is required. This medication should not be used in patients with moderate to severe renal impairment, acute heart failure or myocardial infarction, or patients in acute infection or dehydration states; it should also be temporarily discontinued before and after examinations using contrast agents. Administration is not recommended for pregnant women, women who could become pregnant, nursing mothers, or children under 18 years of age. When taking this medication, regular kidney function, blood tests, and Vitamin B12 levels should be monitored, and alcohol consumption should be avoided. This medication can cause hypoglycemia; therefore, caution is needed when skipping meals or engaging in intense exercise. The risk of hypoglycemia may increase when taken with other blood glucose-lowering agents, necessitating dosage adjustments after consulting a doctor. If surgery is planned, discontinue use 48 hours prior to the surgery, and resume only after confirming normal kidney function post-surgery. In case of severe joint pain or the appearance of blisters on the skin during treatment, inform a doctor immediately and seek treatment. Finally, this medication can interact with several other drugs, so if you are taking other medications, it's essential to inform your doctor or pharmacist, and consult medical personnel immediately if any discomfort arises.

Serious side effects

Hives, anaphylaxis, angioedema, exfoliative skin diseases (including Stevens-Johnson syndrome), acute pancreatitis, acute kidney failure, elevated liver enzymes, blistering similar to dermatitis herpetiformis, severe hypoglycemia, lactic acidosis, severe edema, elevated blood pressure, severe allergic reactions, significant neurological symptoms, liver abnormalities (jaundice)

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication must be stored in a tightly closed container to prevent air and moisture from entering, ideally at a temperature between 1 and 30 degrees Celsius. This storage method helps maintain the drug's effectiveness for a longer period.

Appearance

Bright green, convex on both sides, oval-shaped controlled-release film-coated tablet

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle