Promet XR Extended Release Tablet 50/500 Milligrams

Adult dose

The dosage should be determined based on each patient's current therapeutic regimen, efficacy, and tolerability, without exceeding a maximum daily dose of sitagliptin 100 mg and metformin 2000 mg. This medication should be taken once daily with the evening meal, with gradual dose increments. The extended-release tablet should be swallowed whole and not split or crushed. For the 100/1000 mg extended-release tablet, take 1 tablet once daily. For the 50/500 mg or 50/1000 mg extended-release tablets, take 2 tablets once daily.

This medication contains two components and is primarily used for the treatment of type 2 diabetes. First, one component of this medication is sitagliptin, which can rarely cause serious allergic reactions. These reactions may include anaphylaxis, angioedema, and Stevens-Johnson syndrome, which can cause severe skin damage. If such symptoms are suspected, discontinue use of this medication immediately and consult a physician. Additionally, sitagliptin may cause acute pancreatitis, which indicates inflammation of the pancreas. If symptoms such as abdominal pain, vomiting, or severe indigestion occur during use, notify healthcare professionals immediately. Second, the other component of this medication, metformin, can rarely cause a serious metabolic disorder called lactic acidosis. This condition involves an abnormally high level of lactic acid in the blood, with symptoms including fatigue, muscle pain, shortness of breath, and abdominal pain. If these symptoms occur, discontinue use of the medication immediately and seek medical attention. This medication should not be used in patients with severely impaired kidney function, acute myocardial infarction, heart failure, severe infections, liver dysfunction, pregnant and breastfeeding women. Moreover, this medication should be temporarily discontinued before and after surgery, and can be resumed once the patient’s condition is stable and kidney function is confirmed to be normal. Regular kidney function tests should be performed during the use of this medication, with special attention required for elderly patients or those with compromised kidney function. Hypoglycemic symptoms may occur, so particularly when taken in conjunction with insulin or sulfonylurea agents, blood sugar changes should be carefully monitored. During the use of this medication, excessive alcohol consumption should be avoided, as alcohol may increase the risk of side effects from this medication. Finally, patients taking this medication should have regular blood tests and kidney function tests, as vitamin B12 levels may decrease, necessitating supplementation if needed.

Serious side effects

Hives, angioedema, anaphylaxis, rash, Stevens-Johnson syndrome, cutaneous vasculitis, exfoliative skin disease, pancreatitis (including lethal/non-lethal hemorrhagic or necrotizing pancreatitis), acute pancreatitis, elevated liver enzymes, acute renal failure, worsening kidney function, lactic acidosis, severe swelling (edema), hypoglycemia (including severe), hives, severe allergic reactions, severe skin reactions, respiratory problems, liver disturbances (jaundice), severe

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a tightly closed container to prevent air or moisture from entering. It is best to maintain storage temperatures between 1 to 30 degrees Celsius. Proper storage can help maintain the effectiveness of the medication.

Appearance

Light blue, oval-shaped, bilaterally convex extended-release film-coated tablet

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle