Glycitamet XR Sustained Release Tablet 50/500 mg

Adult dose

To reduce gastrointestinal side effects associated with metformin, this medication should be taken once daily with meals, preferably in the evening, and the dose should be gradually increased. To maintain its sustained-release properties, do not split, crush, grind, or chew the tablet; swallow whole. For this medication 100/1000 mg sustained-release tablets, take 1 tablet once daily. For this medication 50/500 mg sustained-release tablets or 50/1000 mg sustained-release tablets.

This medication is a diabetes treatment containing both sitagliptin and metformin. First, serious allergic reactions may occur while taking this medication; if symptoms such as skin rash, hives, difficulty breathing, or swelling of the face or neck occur, discontinue use immediately and consult a doctor. Additionally, there is a risk of pancreatitis, which is inflammation of the pancreas; if symptoms like abdominal pain, vomiting, or loss of appetite occur, notify healthcare professionals immediately. The metformin component in this medication can cause lactic acidosis, a rare but very dangerous metabolic condition, so it should not be taken when severe dehydration, heart disease, liver disease, severe infection, or acute kidney function decline is present. Particularly, if renal function is moderately or severely impaired, or if there are plans to undergo tests using iodine contrast agents, discontinuation should occur, and it should only be resumed after renal function has been confirmed to be normal. Pregnant women or women who may become pregnant and nursing mothers should not take this medication. There is a risk of hypoglycemia with this medication, so patients should be cautious about missing meals, having irregular eating habits, excessive exercise, or taking it in combination with other hypoglycemic agents. Also, patients with impaired liver or kidney function, elderly patients, and those with poor nutritional status need to be more cautious while taking this medication and should undergo regular blood tests and kidney function tests. Patients scheduled for surgery or with severe infections or trauma should temporarily discontinue this medication, resuming after their condition stabilizes. Finally, it is recommended to avoid alcohol consumption while taking this medication, and if any abnormal symptoms or discomfort are experienced during use, consult a doctor immediately.

Serious side effects

• Hives
• severe swelling (angioedema)
• chest tightness
• difficulty breathing
• anaphylaxis
• Stevens-Johnson syndrome
• severe rash with fever
• blisters
• skin peeling
• pain in oral/ocular mucosa

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• myalgia
• limb pain
• back pain

This medication should be stored in a tightly closed container to prevent air and moisture from entering. It is best to maintain a storage temperature between 1°C and 30°C room temperature. This will help maintain the efficacy and safety of the medication.

Appearance

Bright blue, oval-shaped sustained-release film-coated tablet with a convex surface on both sides.

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle