EUSITAMET XR Sustained Release Tablet 50/500 mg

Adult dose

To reduce gastrointestinal adverse reactions due to metformin, this medication should be taken once daily with dinner, gradually increasing the dosage. To maintain its sustained-release properties, do not crush, break, chew, or divide this medication, just swallow it whole. For this 100/1000 mg sustained-release tablet, take one tablet once daily. For this 50/500 mg sustained-release tablet or 50/1000 mg sustained-release tablet

This medication is a diabetes treatment containing two active ingredients: sitagliptin and metformin. Firstly, sitagliptin may rarely cause serious allergic reactions such as anaphylaxis, angioedema, or severe skin reactions, so if any of these symptoms occur, treatment should be stopped immediately. Additionally, during the administration of this medication, symptoms of acute pancreatitis may occur, necessitating careful observation and immediate cessation of the drug if pancreatitis is suspected. Metformin can cause lactic acidosis, a rare but potentially fatal side effect. Lactic acidosis may present with symptoms such as muscle pain, lethargy, difficulty breathing, abdominal pain, low body temperature, and low blood pressure; therefore, if any of these symptoms appear, consulting a physician immediately is crucial. This medication should not be used in patients with moderate or severe renal impairment, those with acute congestive heart failure or acute myocardial infarction, patients with liver dysfunction, women who are pregnant or breastfeeding, and patients suffering from certain acute illnesses. While on this medication, kidney function, blood tests, and vitamin B12 levels must be monitored regularly, especially in the elderly or those with impaired renal function, who require additional caution. This drug can cause hypoglycemia, especially when taken with other antidiabetic medications such as insulin or sulfonylureas, increasing the risk of hypoglycemic symptoms, which one should be well-informed about. Prior to surgery or examinations using iodine contrast agents, the administration of this medication should be temporarily discontinued and should only be resumed after confirming normal kidney function following testing. Alcohol may increase the risk of lactic acidosis, a side effect of this drug; thus, excessive drinking should be avoided during treatment. Lastly, if sudden skin rashes, vesicles, severe joint pain, or muscle pain occur during the course of taking this medication, healthcare personnel should be promptly notified. Although this medication aids in the treatment of diabetes, adhering to these precautions and undergoing regular check-ups for safe use is very important.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, Stevens-Johnson syndrome, serious skin adverse reactions, severe rash with fever, blistering, desquamation, pain in oral/ocular mucosa, pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing), acute pancreatitis, liver abnormalities (jaundice), elevated liver enzymes, acute renal failure, severe edema, sudden and severe headaches, seizures, altered consciousness

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• myalgia
• limb pain

This medication may be sensitive to air or humidity, so it must be stored in a tightly sealed container. It is also recommended to store the medication at room temperature, specifically between 1 to 30 degrees Celsius, avoiding too hot or too cold conditions.

Appearance

Light blue, oval-shaped, convex on both sides sustained-release film-coated tablet

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle