Sitagliptin/Metformin Extended-Release Tablets 50/1000 mg

Adult dose

The 100/1000 mg extended-release tablets should be taken once daily, with one tablet per dose. Patients taking the 50/500 mg extended-release tablets or the 50/1000 mg extended-release tablets should take two tablets simultaneously, once daily. 1. For patients not currently treated with metformin: The initial dose of this medication is a total daily amount of 100 mg of sitagliptin and 1000 mg of metformin. The initial dose of initial treatment for those unable to achieve sufficient blood sugar control with monotherapy or with sitagliptin monotherapy.

This medication contains sitagliptin and metformin, and is used for diabetes treatment. However, there are several precautions you should be aware of before taking this medication. First, this medication can cause severe allergic reactions, so if you experience symptoms such as a skin rash, difficulty breathing, or swelling of the face or neck, you should stop taking it immediately and inform your healthcare provider. Second, there is a risk of pancreatitis, which is an inflammation of the pancreas. If you experience abdominal pain, nausea, or vomiting while taking this medication, consult your doctor immediately. Third, due to the metformin component, there can be a rare but serious metabolic disorder known as lactic acidosis. Caution is needed if you have severe dehydration, infections, or heart disease. Fourth, this medication should not be taken by patients with decreased kidney function, acute heart conditions, severe infections, or dehydration, and its use should be discontinued for a period before and after surgery. Fifth, it is safe to avoid this medication for women who are pregnant or may become pregnant, as well as nursing mothers. Sixth, during the use of this medication, regular monitoring of kidney function and blood tests should be conducted, and it is recommended to periodically check vitamin B12 levels. Seventh, if taken with other hypoglycemic agents or insulin, there is a risk of hypoglycemia, so pay attention to symptoms and adjust medication dosages if necessary. Eighth, alcohol consumption can increase the risk of lactic acidosis, so excessive drinking should be avoided while taking this medication. Lastly, this medication's safety and efficacy have not been established in children under 18 years of age, so it is advisable not to use it in this population. When taking this medication, be sure to understand these precautions, and consult with your healthcare provider if any abnormal symptoms arise.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, severe allergic reactions, severe skin reactions (including Stevens-Johnson syndrome and exfoliative skin disorders), acute pancreatitis, acute renal failure, severe and debilitating joint pain, blistering-like dermatitis, liver abnormalities (liver dysfunction, jaundice), severe lactic acidosis, hypoglycemia (including severe hypoglycemia), severe edema or urinary abnormalities (deterioration of kidney function and acute renal failure), respiratory issues

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is safe to store it at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain its effectiveness for a longer period.

Appearance

Bright green, oval-shaped extended-release film-coated tablet, convex on both sides

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle