Janux XR Extended-Release Tablet 50/1000 mg (Sitagliptin, Metformin)

Adult dose

For the 100/1000 mg extended-release tablet, take one tablet once daily. For patients taking the 50/500 mg extended-release tablet or the 50/1000 mg extended-release tablet, take two tablets simultaneously once daily. 1. For patients not currently treated with Metformin: the initial dosage is a total daily dose of 100 mg Sitagliptin and 1000 mg Metformin. Gradually increase Metformin.

This medicine contains two components: Sitagliptin and Metformin. Sitagliptin can rarely cause severe allergic reactions, so if skin rashes, difficulty breathing, or swelling of the face or neck occur within three months after administration, use should be immediately discontinued. Additionally, Sitagliptin can cause acute pancreatitis, so if abdominal pain, nausea, or vomiting occur, consult a doctor immediately. Metformin can cause a serious metabolic disorder known as lactic acidosis, which is very rare but can be fatal. Therefore, patients with impaired renal function, liver disease, severe infections, or dehydration should not take this medication. Furthermore, Metformin can cause hypoglycemia, so caution is needed when skipping meals, having irregular meals, or engaging in vigorous exercise. This medication should not be administered to patients with moderate or severe renal impairment, acute heart failure, acute myocardial infarction, severe infections, pregnant or breastfeeding women. If food intake is restricted before and after surgery, this medication should be stopped 48 hours prior to surgery and resumed only after normal renal function is restored. During the use of this medicine, regular monitoring of renal function and blood tests is necessary, and it is advisable to periodically check vitamin B12 levels. Additionally, excessive alcohol consumption can increase the risk of lactic acidosis, so alcoholic beverages should be avoided while taking this medication. This medicine increases the risk of hypoglycemia when combined with other diabetes medications, so symptoms of hypoglycemia should be monitored, and dosage adjustments should be discussed with a doctor if necessary. Lastly, this medication is not recommended for use in pediatric patients under 18 years of age, as its safety and efficacy have not been established.

Serious side effects

Hives, angioedema, anaphylaxis, severe swelling (edema), acute pancreatitis, severe allergic reactions, severe skin adverse reactions (Stevens-Johnson syndrome, exfoliative dermatitis), acute renal failure, difficulty breathing, liver abnormalities (jaundice), lactic acidosis, hypoglycemia, severe neurological symptoms, bullous pemphigoid, severe edema or urinary disturbances

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be kept in a tightly closed container to prevent air and moisture from entering, and it is safe to store it at room temperature, between 1 degree and 30 degrees Celsius. This way, the effectiveness of the medicine can be well-maintained.

Appearance

A bright green, oval-shaped extended-release film-coated tablet with a convex shape on both sides.

Package unit

28 tablets/bottle, 30 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle