Janux XR Extended-Release Tablet 50/500 mg (Sitagliptin, Metformin)

Adult dose

The dosage of this medication should be determined based on each patient’s current treatment regimen, effectiveness, and tolerance, ensuring it does not exceed the maximum recommended daily doses of sitagliptin 100 mg and metformin 2000 mg. This medication is taken once daily in the evening with a meal to reduce gastrointestinal side effects associated with metformin, and the dosage is increased gradually. To maintain the extended-release characteristics, do not split, crush or chew this medication.

This medication contains both sitagliptin and metformin. Sitagliptin can rarely cause serious allergic reactions, so if symptoms such as rash, difficulty breathing, or swelling of the face or lips occur after taking it, you must stop taking it immediately and consult a doctor. Additionally, sitagliptin can cause pancreatitis, which is inflammation of the pancreas, so if symptoms such as abdominal pain, nausea, vomiting, or fever occur, you should inform a healthcare professional immediately. Metformin can cause lactic acidosis, a rare but potentially fatal metabolic disorder, so if symptoms such as sudden muscle pain, difficulty breathing, fatigue, or abdominal pain appear, you should stop taking it immediately and visit a hospital. This medication should not be administered to patients with moderate to severe renal impairment, those with acute cardiovascular disease or acute infection, and women who are pregnant or nursing. Moreover, this medication must be discontinued before undergoing procedures using iodine contrast agents, and can only be resumed after kidney function is confirmed to be normal following the procedure. During treatment, it is essential to have regular kidney function and blood tests, and it’s recommended to periodically check vitamin B12 levels. This medication may interact with other hypoglycemic agents, alcohol, and certain medications, so you must inform your doctor or pharmacist if you are taking any other medications. Hypoglycemia may occur, so meals should be regular, sudden exercise or skipping meals should be avoided, and sugar should be consumed immediately in case of hypoglycemic symptoms. If surgery is planned, the medication should be stopped 48 hours before the procedure, and can be resumed only after kidney function is confirmed to be normal post-surgery. During treatment with this medication, if severe joint pain or skin blisters or rashes occur, you must notify a doctor immediately and receive treatment. Elderly patients are at increased risk of reduced kidney function, thus dosage adjustments and regular examinations are necessary. The safety and efficacy of this medication in children and adolescents under 18 years old have not been sufficiently proven, hence use is not recommended.

Serious side effects

• Urticaria
• angioedema
• anaphylaxis
• rash
• cutaneous vasculitis
• Stevens-Johnson syndrome
• acute pancreatitis
• acute renal failure
• increased liver enzymes
• bullous pemphigoid

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nasopharyngitis
• constipation
• vomiting
• abdominal pain
• muscle pain
• limb pain
• back pain

This medication must be stored in a tightly sealed container to prevent exposure to air and moisture. The recommended storage temperature is between 1 and 30 degrees Celsius. Proper storage ensures the long-term efficacy and safety of the medication.

Appearance

Bright blue, oval, bilayered extended-release film-coated tablet

Package unit

28 tablets/bottle, 30 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle