Nariozenta Duo Tablet 2.5/500 Milligrams

Adult dose

The dosage of this medication should be determined within the limits of the maximum recommended dosage of Linaagliptin 2.5 mg and Metformin 1000 mg, considering each patient's current treatment regimen, efficacy, and tolerance. This medication is taken twice daily with meals. 1. If currently not being treated with Metformin: Take 2.5/500 mg of this medication twice daily, with 1 tablet per dose, increasing to 2.5/1000 mg if necessary.

This medication can cause a rare but serious side effect known as lactic acidosis, and should not be used in patients with impaired kidney function or those with problems related to the heart or liver. It should not be administered to patients who have allergies to any of the ingredients, or those with type 1 diabetes, acute infections, severe dehydration, or certain conditions like acute myocardial infarction. Due to the risk of hypoglycemia, blood sugar changes should be carefully monitored when taken with insulin or sulfonylureas, and insulin or sulfonylurea doses may need to be adjusted as necessary. Elderly patients with declining kidney function should have regular kidney function tests, and this medication should not be used if kidney function falls below certain criteria. If undergoing radiological iodine contrast examination, this medication should be discontinued for a certain period before and after the examination, and should be resumed only after kidney function stabilizes. Patients due for surgery should discontinue this medication 48 hours before the procedure and should not resume until kidney function returns to normal post-operation. If there is suspicion of acute pancreatitis or bullous pemphigoid, this medication should be discontinued immediately and consulted with a physician. Vitamin B12 levels may drop during treatment, so those on long-term therapy should check vitamin B12 levels regularly and supplement if deficient. Women who are pregnant or may become pregnant, as well as breastfeeding mothers should not use this medication; those planning to become pregnant should consult a physician for appropriate treatments. It is recommended not to use this medication in children under 10 years of age as safety and efficacy have not been established. There may be interactions with other medications during use, so any other medications being taken must be disclosed to a physician or pharmacist. In case of overdose, serious side effects such as lactic acidosis may occur, and immediate medical attention is required, which might include procedures like hemodialysis if necessary. This medication should be stored out of the reach of children, kept dry, and should not be transferred to other containers.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, abnormal liver function (abnormal liver function tests, hepatitis, erythema), angina, acute myocardial infarction, unstable angina, cardiac arrest, congestive heart failure, dyspnea, asthma attacks, pneumonia, acute kidney injury, end-stage kidney disease, acute cholangitis, acute cholecystitis, cholangitis, gallstones, vitreous hemorrhage, cerebral infarction, fever, facial edema, facial swelling, death, severe allergic reactions.

Mild side effects

Nasopharyngitis, hypersensitivity, urticaria, hypoglycemia, taste disturbance, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcer formation, abnormal liver function tests, hepatitis, pruritus, erythema, rash, musculoskeletal and connective tissue disorders, increased lipase, increased amylase, constipation, stomatitis, headache, drowsiness, dizziness, sensory loss, fatigue, itching, insomnia, depression, hypertension, vertigo, benign prostatic hyperplasia.

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, ideally at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness over time.

Appearance

Bright yellow, double-convex, oval film-coated tablet

Package unit

60 tablets/Alu-Alu [60 tablets (10 tablets/Alu-Alu x 6)]